A case of brucellosis complicated with fatal capillary leak syndrome

Karsen, Hasan; St, Koruk; Calisur, C; Karagac, L; Duygu, Fazılet

doi:10.4149/bll_2012_115

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…Another mechanism was described in medical literature, two studies reported edema in the course of capillary leak syndrome (CLS) precipitated by Brucellosis [ 4 , 7 ]. CLS is an unusual condition characterized by unexplained capillary hyperpermeability commonly following an inflammatory stimulus such as viral or bacterial infections.…”

Section: Discussionmentioning

confidence: 99%

“…Few cases in the medical literature reported an association between ascites and brucellosis [ 2 , 3 ]; even fewer mentioned peripheral edema emerging in the context of brucellosis [ 4 ]. Most cases found in the literature attributed ascites to a specific underlying etiology such as liver disease or spontaneous bacterial peritonitis [ 3 , 5 , 6 ], whereas peripheral edema rarely accompanied capillary leak syndrome [ 4 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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A rare presentation of peripheral edema and ascites in a 10-year-old child with brucellosis: A case report

Shebli

Batal

Chihab

et al. 2022

Annals of Medicine &Amp; Surgery

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Introduction and importance: Brucellosis is a common infection in Mediterranean region that manifests with various symptoms. Brucellosis should be considered as a possible cause of recurrent fever even if the symptoms are not suggestive of brucellosis. Case presentation We report a case of 10-year-old child with no significant past medical history who presented with a 4-day period peripheral edema and ascites without fever, arthralgia or abdominal pain. Clinical discussion Proper investigations showed normal cardiac and renal functions; ultrasonography showed no portal vein hypertension. Albumin and total protein were also within normal. Complete blood count revealed pancytopenia; bone marrow aspiration and biopsy revealed hypercellularity that could be attributed to hypersplenism as a possible cause. Liver biopsy revealed non-specific inflammatory findings and also did not lead to a definite diagnosis. While broadening the scope of deferential diagnosis in order to reach a final diagnosis, Wright serum agglutination was tested positive (1/640) and we diagnosed a brucellosis infection. A proper management with Antibiotics ensued; the patient had uneventful recovery on treatment until complete clinical and imaging resolution of signs and symptoms. Conclusion Although brucellosis is considered a multi-systemic disease with atypical presentations, early diagnosis of brucellosis with management causes rapid recovery and favorable prognosis. We report a case of ascites and edema in context of Brucella infection which was completely resolved after treatment. This condition is rare especially in previously healthy child and after excluding other possible causes. We aim to share our case to keep brucellosis in mind as a differential diagnosis when dealing with infectious diseases with non-specific symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A rare presentation of peripheral edema and ascites in a 10-year-old child with brucellosis: A case report

Shebli

Batal

Chihab

et al. 2022

Annals of Medicine &Amp; Surgery

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“…Ainsi, deux cas de brucellose se sont compliqués de SFCS [33,34]. Une observation isolée rapporte un SFCS accompagnant une infection à Chlamydia pneumoniae [35].…”

Section: Les Infections Bactériennesunclassified

Syndrome de fuite capillaire idiopathique et formes secondaires : une revue systématique de la littérature

Duron

Delestre

Amoura

et al. 2015

La Revue de Médecine Interne

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Idiopathisches systemisches Capillary-leak-Syndrom (Clarkson-Syndrom)

Dasdelen

Grebe

2018

Internist

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This case report describes the episodic occurrence of severe generalized edema in a young female patient, who developed hypertension with a massive hemoconcentration (hematocrit >0.5, hemoglobin >20g/dl) and hypoalbuminemia during the course of these acute disease phases. After the first two disease exacerbations were overcome, there was a complete regression of symptoms. After a long symptom-free interval, a new exacerbation occurred as a result of which critical organ ischemia occurred due to the severe hypotension and massive edema. Despite all treatment measures a severe compartment syndrome of the lower extemities with subsequent rhabdomyelosis developed. The patient ultimately died as a result of treatment-refractory cardiovascular failure. The idiopathic systemic capillary leak syndrome (SCLS, also known as Clarkson disease) is a rare and potentially life-threatening disease with a high mortality. Since the first description of the disease only approximately 500 cases have been published worldwide. The pathophysiology of this disease remains unclear despite all previous attempts at clarification. Regulation processes of endothelial permeability seem to be essentially disturbed. Affected patients have a monoclonal gammopathy of undetermined signficance conspicuously often; however, the knowledge of the limited treatment options is of fundamental importance for the prognosis and overall survival of patients.

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A case of brucellosis complicated with fatal capillary leak syndrome

Cited by 3 publications

References 10 publications

A rare presentation of peripheral edema and ascites in a 10-year-old child with brucellosis: A case report

A rare presentation of peripheral edema and ascites in a 10-year-old child with brucellosis: A case report

Syndrome de fuite capillaire idiopathique et formes secondaires : une revue systématique de la littérature

Idiopathisches systemisches Capillary-leak-Syndrom (Clarkson-Syndrom)

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