A case of bullous pemphigoid induced by torsemide

Wurtz, Paul; Borucki, Robert; Georgesen, Corey

doi:10.1016/j.jdcr.2022.06.023

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…In the end, we included seventeen research that met the criteria. Wurtz, 2022 23 Nebraska Case report patient Torsemide should be taken into consideration as a possible culprit when the history, examination, and histology are in line with DABP, as it is possible that it could cause BP by processes similar to those of furosemide.…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen case reports 8,9,11,12,14,15,[17][18][19][20][21]23,24 were reporting the occurrence of bullous pemphigoid after medication use. The drug most frequently reported was dipeptidyl peptidase-4 inhibitors (vildagliptin, sitagliptin, linagliptin) while other medications reported include immunomodulatory agents (teriflunomide, ustekinumab, pembrolizumab), anticonvulsants (gabapentin, levetiracetam), tyrosine kinase inhibitor (nintedanib), antibiotics (doxycycline), anticoagulant (rivaroxaban), diuretics (torsemide), and mRNA Covid-19 vaccine (Pfizer).…”

Section: Occurrence Of Bullous Pemphigoid In Association With Medicat...mentioning

confidence: 99%

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Association Between Medication Use and Bullous Pemphigoid: A Ten-Year Systematic Review

Agnes Marpaung,

Retnawati Sihombing

2024

JARMHS

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Background: Bullous pemphigoid is an autoimmune subepithelial disease. It was associated with autoantibodies targeting hemidesmosome protein BPAG1 and BPAG2. The incidence of bullous pemphigoid has increased 1.9-4.3 times in the past two decades, possibly due to increased life expectancy, medication use, and improved diagnostic methods. Trigger factors of BP included drugs, physical factors, radiotherapy, trauma, and thermal exposure. The aim: This study aims to determine association between medication use and bullous pemphigoid. Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2014 and 2024 were taken into account. Several different online reference sources, like Pubmed and ScienceDirect, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done. Results: In the PubMed database, the results of our search brought up 1,662 articles, whereas the results of our search on ScienceDirect brought up 1,143 articles. The results of the search conducted by title screening yielded a total of 13 articles for PubMed and 32 articles for ScienceDirect. We compiled a total of 26 papers, 8 of which came from PubMed and 18 of which came from ScienceDirect. We excluded 2 review articles, 1 duplicate article, 3 non-full text articles, and 3 articles having insufficient outcomes. In the end, we included seventeen research that met the criteria. Conclusion: Our study suggests that dipeptidyl peptidase-4 inhibitors and aldosterone antagonists are associated with BP. Other medications, such as immunomodulatory agents, anticonvulsants, tyrosine kinase inhibitors, antibiotics, anticoagulants, diuretics, and mRNA COVID-19 vaccine, may be associated with BP. Regarding these results, clinicians should pay close attention to prescribing the medicine to their patients.

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Section: Resultsmentioning

confidence: 99%

Section: Occurrence Of Bullous Pemphigoid In Association With Medicat...mentioning

confidence: 99%

Association Between Medication Use and Bullous Pemphigoid: A Ten-Year Systematic Review

Agnes Marpaung,

Retnawati Sihombing

2024

JARMHS

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“…In one case report, switching from furosemide to bumetanide resulted in the complete clinical remission of BP [161], although bumetanide itself has also been associated with BP development in some patients [162,163]. Finally, torsemide has been linked to DABP in one case report due to its temporal relationship and structural similarity to furosemide [164].…”

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confidence: 99%

From Molecular Insights to Clinical Perspectives in Drug-Associated Bullous Pemphigoid

de Nicolas-Ruanes,

Ballester-Martinez,

Garcia-Mouronte

et al. 2023

IJMS

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Bullous pemphigoid (BP), the most common autoimmune blistering disease, is characterized by the presence of autoantibodies targeting BP180 and BP230 in the basement membrane zone. This leads to the activation of complement-dependent and independent pathways, resulting in proteolytic cleavage at the dermoepidermal junction and an eosinophilic inflammatory response. While numerous drugs have been associated with BP in the literature, causality and pathogenic mechanisms remain elusive in most cases. Dipeptidyl peptidase 4 inhibitors (DPP4i), in particular, are the most frequently reported drugs related to BP and, therefore, have been extensively investigated. They can potentially trigger BP through the impaired proteolytic degradation of BP180, combined with immune dysregulation. DPP4i-associated BP can be categorized into true drug-induced BP and drug-triggered BP, with the latter resembling classic BP. Antineoplastic immunotherapy is increasingly associated with BP, with both B and T cells involved. Other drugs, including biologics, diuretics and cardiovascular and neuropsychiatric agents, present weaker evidence and poorly understood pathogenic mechanisms. Further research is needed due to the growing incidence of BP and the increasing identification of new potential triggers.

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Torasemide

2022

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A case of bullous pemphigoid induced by torsemide

Cited by 3 publications

References 9 publications

Association Between Medication Use and Bullous Pemphigoid: A Ten-Year Systematic Review

Association Between Medication Use and Bullous Pemphigoid: A Ten-Year Systematic Review

From Molecular Insights to Clinical Perspectives in Drug-Associated Bullous Pemphigoid

Torasemide

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