A case of canine chimerism diagnosed using coat color tests

Dreger, Dayna L.; Schmutz, S. M.

doi:10.1016/j.mcp.2012.03.004

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Such a situation is usually caused by a spontaneous fusion of two zygotes. Recently, Dreger and Schmutz () described a female dog ( SRY ‐negative) with an unusual coat colour phenotype and normal genitalia, in which the chimeric status was confirmed by the use of molecular analysis of two genes controlling coat colour. It should be pointed out that the application of molecular studies of polymorphic markers is required to distinguish between chimerism and mosaicism.…”

Section: Introductionmentioning

confidence: 99%

A Case of Leucocyte Chimerism (78,XX/78,XY) in a Dog with a Disorder of Sexual Development

Szczerbal

Nowacka‐Woszuk

Niżański

et al. 2014

Reprod Domestic Animals

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A 1-year-old Shih Tzu dog was presented for examination because of abnormal external genitalia. A residual penis with a prepuce was located in a position typical of a male. The dog had no palpable testicles or scrotum. The ultrasound examination revealed the presence of the prostate, but the gonads remained undetectable. Cytogenetic analysis performed on chromosome preparations obtained from lymphocyte culture showed two cell lines - 78,XX and 78,XY. Molecular analysis of 14 polymorphic microsatellite markers allowed us to distinguish leucocyte chimerism from whole body chimerism. The presence of 3 or 4 alleles was confirmed in DNA isolated from blood, while in DNA isolated from hair follicles only 1 or 2 alleles were detected. The case was classified as leucocyte 78,XX/78,XY chimerism. Our study showed that XX/XY leucocyte chimerism might be associated with disorder of sexual development in dogs. Furthermore, it is emphasized that the use of cytogenetic study, in combination with analysis of polymorphic markers in DNA isolated from different somatic cells, facilitates distinguishing between leucocyte and whole body chimerism.

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Section: Introductionmentioning

confidence: 99%

A Case of Leucocyte Chimerism (78,XX/78,XY) in a Dog with a Disorder of Sexual Development

Szczerbal

Nowacka‐Woszuk

Niżański

et al. 2014

Reprod Domestic Animals

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Feline chimerism revealed by DNA profiling

et al. 2020

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SummaryIn dogs and cats, unusual coat colour phenotypes may result from various phenomena, including chimerism. In the domestic cat, the tortoiseshell coat colour that combines red and non‐red hairs is the most obvious way to identify chimeras in males. Several cases of tortoiseshell males have been reported, some of which were diagnosed as chimeras without any molecular confirmation. Here, we report the case of a female feline chimera identified thanks to its coat colour and confirmed through DNA profiling and a coat colour test. We ruled out the hypothesis of mosaicism and aneuploidy. All the data were consistent with a natural case of female chimerism.

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A case of canine chimerism diagnosed using coat color tests

Cited by 2 publications

References 10 publications

A Case of Leucocyte Chimerism (78,XX/78,XY) in a Dog with a Disorder of Sexual Development

A Case of Leucocyte Chimerism (78,XX/78,XY) in a Dog with a Disorder of Sexual Development

Feline chimerism revealed by DNA profiling

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