A Case of Capecitabine-Induced Sarcoidosis

Abstract

Sarcoidosis is an inflammatory disease involving multiple-organs with an unknown cause. The new onset of sarcoidosis associated with therapeutic agents has been observed in 3 clinical settings; tumor necrosis factor antagonists in autoimmune rheumatologic diseases, interferon alpha with or without ribavirin in patients with chronic hepatitis C or melanoma, and antineoplastic agent-associated sarcoidosis in patients with hematologic malignancies. Here, we report a female patient who developed sarcoidosis after capecitabine treatment as an adjuvant chemotherapy for sigmoid colon cancer. To our knowledge, this is the first report of a capecitabine-induced sarcoidosis.

A Case of Abdominal Sarcoidosis in a Patient with Acute Myeloid Leukemia

“…Our patient did not receive a bone marrow transplant, but she was treated with several chemotherapeutic agents as part of the clinical trial. Granulomatous disease has been associated with exposure to chemotherapy agents, for example, capecitabine, interferon beta, and particularly heavy metals or methotrexate [7, 8]. It is not clear whether this was a factor in the case presented here.…”

A Case of Sarcoidosis Associated with Capecitabine

“…It does not fall into the four drug categories that cause sarcoid-like reactions in the literature (6, 10). However, a case of capecitabine-associated sarcoidosis in a patient with colorectal cancer has previously been reported in the literature (7). Our case is the rst case that developed sarcoidosis due to adjuvant capecitabine used in breast cancer treatment.…”

“…It is used in breast cancer and colorectal cancer treatments due to its effectiveness, reliability and good tolerability (5,6). To this date there is only one reported case of sarcoidosis that developed after capecitabine treatment in a patient diagnosed with colon cancer (7). Here, we aimed to present a case of sarcoidosis that developed after adjuvant capecitabine treatment in a patient diagnosed with breast cancer.…”

Sarcoidosis with multiorgan involvement and cutaneous manifestations after colonic adenocarcinoma resection

“…[7] Capecitabine and FOLFOX were found to be associated with sarcoidosis and/or granulomatous reactions in previous publications, suggesting a possible explanation of mechanism in our case, as well. [1415]…”