A case of Caplan syndrome in a recently diagnosed patient with silicosis: A case report

Alaya, Zeineb; Braham, Mouna; Aissa, S.; Kalboussi, Houda; Bouajina, E.

doi:10.1016/j.radcr.2018.03.004

Cited by 6 publications

(3 citation statements)

References 12 publications

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“…It has been reported there is an association between silicosis and RA, mainly affecting patients with ACPA-positive RA [ 54 ]. Chronic exposure to silica can lead to rheumatoid pneumoconiosis, also known as Caplan’s syndrome, a rare disease of RA patients who have developed silicosis [ 55 ].…”

Section: Epidemiologic Overviewmentioning

confidence: 99%

Management of Rheumatoid Arthritis: An Overview

Radu

Bungău

2021

Cells

485

185

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Rheumatoid arthritis (RA) is a multifactorial autoimmune disease of unknown etiology, primarily affecting the joints, then extra-articular manifestations can occur. Due to its complexity, which is based on an incompletely elucidated pathophysiological mechanism, good RA management requires a multidisciplinary approach. The clinical status of RA patients has improved in recent years due to medical advances in diagnosis and treatment, that have made it possible to reduce disease activity and prevent systemic complications. The most promising results were obtained by developing disease-modifying anti-rheumatic drugs (DMARDs), the class to which conventional synthetic, biologic, and targeted synthetic drugs belong. Furthermore, ongoing drug development has led to obtaining molecules with improved efficacy and safety profiles, but further research is needed until RA turns into a curable pathology. In the present work, we offer a comprehensive perspective on the management of RA, by centralizing the existing data provided by significant literature, emphasizing the importance of an early and accurate diagnosis associated with optimal personalized treatment in order to achieve better outcomes for RA patients. In addition, this study suggests future research perspectives in the treatment of RA that could lead to higher efficacy and safety profiles and lower financial costs.

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Section: Epidemiologic Overviewmentioning

confidence: 99%

Management of Rheumatoid Arthritis: An Overview

Radu

Bungău

2021

Cells

485

185

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“…Even though Caplan's syndrome was found in patients with a variety of pneumoconioses [6], it mostly affects individuals with prolonged exposure to crystalline silica [7]. Although the relationship between silica exposure, pneumoconiosis, and rheumatoid arthritis has been well researched [8] and confirmed [9], the pathophysiology of Caplan's syndrome is still under investigation.…”

Section: Discussionmentioning

confidence: 99%

“…It is a rare condition defined as the association of silicosis and rheumatoid arthritis. The reported prevalence of Caplan's syndrome ranges between 0.4 % and 1.5 % [1]. Although initially described in workers exposed to coal mine dust, its prevalence is higher in those exposed to crystalline silica or diagnosed with silicosis [2,3].…”

Section: Introductionmentioning

confidence: 99%

Caplan’s Syndrome (rheumatoid pneumoconiosis), a rare disease entity: case report

Diaconu

Moise

Rașcu

2020

Romanian Journal of Occupational Medicine

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Caplan’s syndrome, known as rheumatoid pneumoconiosis, was first described by Anthony Caplan in 1953, who identified a rare lung disorder found in coal mine workers with rheumatoid arthritis. Although Caplan’s syndrome was found in patients with a variety of pneumoconioses, it mostly affects individuals with long exposure to crystalline silica. We present a case of Caplan’s syndrome in a patient with advanced stage of rheumatoid arthritis and silicosis.

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