A Case of Carcinosarcoma of the Breast Presenting as Inflammatory Carcinoma and Review of the Literature

Lakshmi, Harish Neelamraju; Saini, Devendra; Prakash, Om; Verma, Naveen

doi:10.7759/cureus.10104

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…As H.N. Lakshmi, D. Saini, P. Om and N. Verma report in their article [24], a carcinosarcoma of the breast can present as an inflammatory carcinoma, just as other oncological diseases outside the breast tissue can mimic an IBC, as demonstrated by G. Panse, V. Bossuyt and C.J. Ko, in whose article they report a metastatic serous carcinoma presenting as inflammatory carcinoma over the breast.…”

Section: Discussionmentioning

confidence: 94%

Inflammatory Carcinoma in a 50-year-old Female Patient

Izzo,

Santini

et al. 2023

Preprint

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(1) Background: This case presents a rare and challenging clinical scenario involving a 50-year-old female patient diagnosed with Inflammatory Carcinoma, a particularly aggressive and rapidly growing form of breast cancer. The disease is characterized by heat, redness, swelling and noticeable changes in the breast's skin texture, resembling the skin of an orange (peau d'orange). This case is important because it contributes to the limited clinical literature on such aggressive forms of breast cancer.; (2) Methods: The multidisciplinary approach was employed. Diagnostic procedures such as imaging tests, biopsy, and histopathological examination were performed to confirm the diagnosis of Inflammatory Carcinoma and assess the extent of the disease. The presence of the HER2 protein on the tumor cells supported the selection of a combination therapy involving systemic chemotherapy and targeted biological therapy.; (3) Results: The patient responded positively to the combination therapy consisting of systemic chemotherapy and targeted biological therapy. The aggressive nature of Inflammatory Carcinoma, characterized by rapid growth and distinct skin changes, was effectively addressed. The presence of the HER2 protein on the tumor cells indicated the potential efficacy of the combination therapy in aggressive forms of breast cancer.; (4) Conclusions: This case highlights the critical importance of a multidisciplinary approach in managing complex cases of breast cancer, especially rare and aggressive subtypes like Inflammatory Carcinoma. The positive response of the patient to the combination therapy involving systemic chemotherapy and targeted biological therapy demonstrates the potential for favorable outcomes in aggressive disease presentations.

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Section: Discussionmentioning

confidence: 94%

Inflammatory Carcinoma in a 50-year-old Female Patient

Izzo,

Santini

et al. 2023

Preprint

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“…Collision tumor refers to the tumor formed by two primary tumors infiltrating each other, i.e., when two separate tumors occur in the same site. Carcinosarcoma is a rare form of collision mammary cancer with mixed epithelial and sarcomatoid components, accounting for <0.1% of all breast malignancies [ 6 ]. We report a case of colliding breast neoplasm consisting of BC and NHL that is much rarer than carcinosarcoma.…”

Section: Discussionmentioning

confidence: 99%

Invasive ductal carcinoma and small lymphocytic lymphoma/chronic lymphocytic leukemia manifesting as a collision breast tumor: A case report and literature review

Chen

Liao

et al. 2021

Open Life Sciences

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Collision breast tumors, consisting of breast cancer (BC) and non-Hodgkin’s lymphoma (NHL), are extremely rare. Here we report the case of a 64-year-old woman with a collision tumor in her left breast mass that was composed of invasive ductal carcinoma and small lymphocytic lymphoma/chronic lymphocytic leukemia. In addition, we reviewed the published comparable English-language literature. Collision breast tumor composed of BC and NHL is extremely rare. For that reason, there is a lack of consensus about the underlying mechanism, and diagnosing it without delay remains a complex clinical challenge. We found that post-menopausal, age-related estrogen levels changes and Epstein-Barr virus infection are possible pathogenic factors. However, the symptoms are almost identical, and it is difficult to distinguish a simple breast tumor from a breast collision tumor. In this study, we reviewed the clinical features of all patients with BC and NHL colliding breast tumors; this information might enable early identification and prevention of misdiagnosis.

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Carcinosarcoma of the breast: Facing the challenge of a rare nosologic entity

Mastoraki,

Tsamopoulou,

Stamatis

et al. 2025

World J Clin Cases

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Carcinosarcoma (CS), also known as metaplastic breast carcinoma with mesenchymal differentiation, is one of the five distinct subtypes of metaplastic breast cancer. It is considered as a mixed, biphasic neoplasm consisting of a carcinomatous component combined with a malignant nonepithelial element of mesenchymal origin without an intermediate transition zone. Although cellular origin of this neoplasm remains controversial, most researchers declare that neoplastic cells derive from a cellular structure with potential biphasic differentiation. Despite recent research on the therapeutic strategies against CS neoplastic disorders, surgical resection appears the only potentially curative approach. Since CS metastasize by the lymphatic route, axillary assessment with sentinel lymph node biopsy and/or axillary lymph node dissection is always implemented. Nevertheless, the tumor also presents a hematogenous metastatic pattern including pleural, pulmonary, liver, brain and less commonly bone metastases. Thus, surgical removal of breast CS does not necessarily ensure patient’s long-term recovery. Moreover, alternative therapies, such as radio- and chemotherapy proved insufficient and 5-year survival rate is limited. Nevertheless, there is evidence that following surgery, the combination of radio and chemotherapy is associated with a better prognosis than either treatment alone. The aim of this review is to evaluate the results of surgical treatment for breast CS with special reference to the extent of its histological spread. Clinical features, histogenesis, morphological and immunochemical findings are discussed, while the role of current diagnostic and therapeutic management of this aggressive neoplasm is emphasized.

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A Case of Carcinosarcoma of the Breast Presenting as Inflammatory Carcinoma and Review of the Literature

Cited by 4 publications

References 17 publications

Inflammatory Carcinoma in a 50-year-old Female Patient

Inflammatory Carcinoma in a 50-year-old Female Patient

Invasive ductal carcinoma and small lymphocytic lymphoma/chronic lymphocytic leukemia manifesting as a collision breast tumor: A case report and literature review

Carcinosarcoma of the breast: Facing the challenge of a rare nosologic entity

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