A case of cardiomyopathy in the course of colchicine poisoning due to accidental ingestion of Colchicum autumnale

Yokoyama, Tetsuji; Otsuki, Ikuto; Kimijima, Tomohiko; Kawaguchi, Ryoichi; Takakuwa, K; Nakabayashi, Kenichi

doi:10.3918/jsicm.29_43

Cited by 1 publication

(1 citation statement)

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“…Additionally, three more such cases occurred in 2022, resulting in two deaths, indicating that lethal cases of this type of poisoning still occur. 1 , 2 We encountered a fatal case of colchicine poisoning because of the accidental ingestion of Colchicum autumnale , and we describe it here.…”

Section: Figmentioning

confidence: 94%

Beware of accidental ingestion of Colchicum autumnale mistaken for Allium victorialis

Nara

Nakae

Irie

et al. 2023

Acute Medicine & Surgery

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Dear Editor, According to the statistical data on food poisoning from the Ministry of Health, Labor, and Welfare, two cases of colchicine poisoning occurred in 2021, resulting in one death. Additionally, three more such cases occurred in 2022, resulting in two deaths, indicating that lethal cases of this type of poisoning still occur. 1,2 We encountered a fatal case of colchicine poisoning because of the accidental ingestion of Colchicum autumnale, and we describe it here.An 86-year-old man with a history of diabetes mellitus, chronic heart failure, atrial fibrillation, severe tricuspid regurgitation, postoperative gastric cancer status, and irondeficiency anemia had accidentally ingested Colchicum autumnale (including the stem at the base and 2 to 3 leaves, but no bulbs), which had grown in his garden in the form of tempura. The patient developed diarrhea the day after ingestion. However, he refused hospitalization and was observed at home. Three days after the ingestion, the patient experienced difficulty moving and was taken by ambulance to a nearby hospital.On admission, he had developed multiple organ failure, including circulatory shock, acute liver failure, acute kidney injury (AKI), and coagulation disorders. The patient was transferred to our hospital for critical care. He presented with a consciousness level corresponding to a score of 12 on the Glasgow Coma Scale (E4V2M6) and was administered noradrenaline. On physical examination, his blood pressure was 137/64 mm Hg, heart rate was 98 beats per minute, respiratory rate was 28 breaths per minute, and body temperature was 37.1°C. The results of his blood tests were as follows: white blood cell count of 9600/μL, hemoglobin of 13.7 g/dL, and platelet count of 11.8 × 10 4 / μL. The results of the coagulation tests were prothrombin time-international normalized ratio (PT-INR), 3.56; D-dimer, 177.0 μg/mL; fibrin degradation product (FDP), 433.0 μg/mL; and an acute disseminated intravascular coagulation (DIC) score of 6 points. Biochemical tests revealed: aspartate aminotransferase (AST), 635 U/L; alanine aminotransferase (ALT), 250 U/L; lactate dehydrogenase (LD IFCC), 2294 U/L; alkaline phosphatase (ALP IFCC), 404 U/L; creatine kinase (CK), 1216 U/L; blood urea nitrogen (BUN), 50.8 mg/dL; creatinine (CRE), 3.30 mg/ dL; C-reactive protein (CRP), 10.48 mg/dL; and blood

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Section: Figmentioning

confidence: 94%