A case of cervical metastases from temporal bone carcinoid

Pellini, Raul; Ruggieri, M; Pichi, Barbara; Covello, Renato; Danesi, Giovanni; Spriano, Giuseppe

doi:10.1002/hed.20197

Cited by 25 publications

(16 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Even if patients do not complain of any symptoms, patients with carcinoid tumors should be followed up carefully using effective inspection methods. We reviewed 50 cases that described skeletal metastasis from carcinoid tumors (3,(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). The characteristics of the reported patients are shown in Table Ⅰ.…”

Section: Discussionmentioning

confidence: 99%

Skeletal metastasis of carcinoid tumors: Two case reports and review of the literature

et al. 2012

View full text Add to dashboard Cite

Abstract. Carcinoid tumors are neuroendocrine neoplasms derived from enterochromaffin cells. Skeletal metastases from carcinoid tumors are considered to be extremely rare. In this study, we present two cases of carcinoid tumors that metastasized to the bone. Furthermore, we review 50 published case reports and reveal the features of skeletal metastasis of carcinoid tumors. The first case involved a 59-year-old man with a history of multiple metastases of a lung carcinoid tumor. The patient complained of back pain and numbness in the lower limbs. Magnetic resonance imaging revealed metastases in the thoracic spine. A spinal decompression was performed and the symptoms were resolved. The second case involved a 74-year-old man had been diagnosed with a lung carcinoid tumor 15 years previously and complained of left thigh pain. A radiograph showed osteolytic lesions in the shaft of the left femur. We repaired the femur using an intramedullary nail following curettage of the tumor. A radiograph of the femur revealed a callus on the pathological fracture. The patient was able to walk using a crutch 3 months after surgery. We reviewed 50 cases that described skeletal metastasis from carcinoid tumors. The average age of the patients was 54.9 years and 33 patients (66%) were male. The most common site of skeletal metastasis was the spine. We also investigated the survival rate of patients who developed skeletal metastasis from carcinoid tumors. The findings showed that survival of patients who developed osteolytic skeletal metastasis was worse than that of patients who developed osteosclerotic skeletal metastasis.

show abstract

Section: Discussionmentioning

confidence: 99%

Skeletal metastasis of carcinoid tumors: Two case reports and review of the literature

et al. 2012

View full text Add to dashboard Cite

show abstract

“…In addition, immunohistochemistry was not done in 16 out of 19 MEA reported cases, which suggests that the percentage of MEA probably represents less than 20% of the cases. Pellini et al presented the only case of middle ear free, temporal bone carcinoid metastasis to the cervical lymph nodes [20]. …”

Section: Discussionmentioning

confidence: 99%

Middle ear glandular neoplasms: adenoma, carcinoma or adenoma with neuroendocrine differentiation: a case series

Saliba

Evrard

2009

Cases Journal

View full text Add to dashboard Cite

IntroductionMiddle ear glandular neoplasms are infrequent causes of a middle ear mass. They can have exocrine and/or neuroendocrine differentiation. It is currently thought that these tumors are indistinguishable each from another. Herein, we present a new case of a middle ear glandular neoplasm. Our objective is to review all cases described in the literature in order to identify the clinical features, the gross pathology, the histopathology, the immunohistochemistry, to discuss the differential diagnosis, the treatment, the rate of recurrence, the follow-up, the incidence of metastasis, the prognosis and to present a new classification of middle ear glandular neoplasm.Case presentationMethodsWe performed a MEDLINE database search for MEA-related articles published between 1950 and March 2008. The information from the reports was analyzed.ResultsNinety-four patients with a middle ear adenoma are included in this report. We uncovered 75 patients with a carcinoid tumor and 19 patients with a middle ear adenoma diagnosis; the most common presenting symptom was a conductive hearing loss. Middle ear adenomas are lesions that are typically white, gray or reddish brown. They are grossly vascular and well circumscribed, but not encapsulated, and can entrap and destroy the ossicles. Histologically, the cuboidal to low columnar cells are arranged in a solid, trabecular or glandular architecture. The tumor's cells are immunohistochemically positive for a variety of keratin antibodies and most of them are also positive for neuroendocrine markers. Surgical excision is the treatment of choice. Local recurrence following complete excision is quite uncommon and metastases are rare.ConclusionsOur study and the review of the literature showed adenomas and carcinoid tumors of the middle ear to be essentially indistinguishable benign tumors with metastatic potential. Based on the presence or absence of immunohistochemical markers and metastasis, we have classified these lesions into three types. Complete surgical treatment is recommended with an indefinite follow-up for possible recurrence.

show abstract

“…In 2005, Pellini et al [18] reported the case of a 55-year-old female with multiple cervical metastases almost 3 years after the diagnosis of a primary carcinoid of the temporal bone. Histologic examination after a modified radical neck dissection was suggestive of lymph node metastases from a carcinoid tumor.…”

Section: Middle Ear Carcinoids With Regional Metastasesmentioning

confidence: 98%

Primary carcinoid tumor of the middle ear: A potentially metastasizing tumor

Ferlito

Devaney

Rinaldo

2006

Acta Oto-Laryngologica

View full text Add to dashboard Cite

The concept of a carcinoid tumor in the gastrointestinal tract and lung is well established; less often, patients develop carcinoid tumors in the head and neck region. One particularly uncommon site of origin of carcinoid tumors in the head and neck area is the middle ear. Middle ear carcinoids have previously been approached as benign entities, lacking any capacity for metastasizing. A critical review of the literature, however, disclosed a small number of cases in which middle ear carcinoid tumors have given rise to regional (cervical node) metastases. This in turn suggests that, as is the case with pulmonary carcinoid tumors, middle ear carcinoids should be thought of as low-grade malignancies which, while relatively slow-growing, nevertheless possess a limited capacity for spreading to regional lymph nodes. To date, distant metastases have not been associated with middle ear carcinoid tumors.

show abstract

A case of cervical metastases from temporal bone carcinoid

Cited by 25 publications

References 6 publications

Skeletal metastasis of carcinoid tumors: Two case reports and review of the literature

Skeletal metastasis of carcinoid tumors: Two case reports and review of the literature

Middle ear glandular neoplasms: adenoma, carcinoma or adenoma with neuroendocrine differentiation: a case series

Primary carcinoid tumor of the middle ear: A potentially metastasizing tumor

Contact Info

Product

Resources

About