A case of cervical OPLL and DISH mimicking stroke

Prabhu, Rudra Mangesh; Rathod, Tushar; Mohanty, Shubhranshu S.; Hadole, Bhushan S.; Marathe, Nandan; Rai, Abhishek Kumar

doi:10.25259/sni_247_2022

Cited by 2 publications

(2 citation statements)

References 8 publications

(10 reference statements)

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“…DCM can be secondary to osteoarthritic degeneration or to ligamentous ossifications such as the Ossification of the Posterior Longitudinal Ligament (OPLL) or the ossification of the Ligament Flavum (OLF) (Nouri et al, 2015). OPLL, frequently in association with DISH, can result in various degrees of neurological complications that can range from a slowly progressive painless myelopathy to a rapid progression of a neurological deficit even after minor injury (Takayuki et al, 2021;Prabhu et al, 2022). The physical and socioeconomic burden of disability associated with DCM is expected to grow evenly, due to the ageing population (Badhiwala et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Evidence for a genetic contribution to the ossification of spinal ligaments in Ossification of Posterior Longitudinal Ligament and Diffuse idiopathic skeletal hyperostosis: A narrative review

Couto

Parreira²,

Power³

et al. 2022

Front. Genet.

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Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Ossification of the Posterior Longitudinal Ligament (OPLL) are common disorders characterized by the ossification of spinal ligaments. The cause for this ossification is currently unknown but a genetic contribution has been hypothesized. Over the last decade, many studies on the genetics of ectopic calcification disorders have been performed, mainly on OPLL. Most of these studies were based on linkage analysis and case control association studies. Animal models have provided some clues but so far, the involvement of the identified genes has not been confirmed in human cases. In the last few years, many common variants in several genes have been associated with OPLL. However, these associations have not been at definitive levels of significance and evidence of functional significance is generally modest. The current evidence suggests a multifactorial aetiopathogenesis for DISH and OPLL with a subset of cases showing a stronger genetic component.

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Section: Introductionmentioning

confidence: 99%

Evidence for a genetic contribution to the ossification of spinal ligaments in Ossification of Posterior Longitudinal Ligament and Diffuse idiopathic skeletal hyperostosis: A narrative review

Couto

Parreira²,

Power³

et al. 2022

Front. Genet.

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“…The differential diagnosis should be done with AS (12), spondylosis (spine generalized osteoarthritis) (14,15) and the ossification of the posterior longitudinal ligament (OPLL) (16)(17)(18)(19) (figure 2). The following table I sums up the differences between these diseases.…”

Section: Differential Diagnosismentioning

confidence: 99%

The Diffuse Idiopathic Skeletal Hyperostosis (DISH): A Literature Review on the Rehabilitation Treatment

Oliva,

Agnes,

Strollo

et al. 2023

Muscle Ligaments and Tendons J

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Introduction. The diffuse idiopathic skeletal hyperostosis (DISH), also known as Forestier-Rotès-Querol disease, is a systemic pathology characterized by the diffuse ossification of the ligaments of the spinal column. It can be linked to several metabolic disorders, such as obesity and type II diabetes, and its prevalence among the elderly population is high. DISH may be asymptomatic and only acknowledged in the imaging, or it can be associated to serious clinical conditions like stiffness, pain and reduced spine mobility. At the moment, specific guidelines for the treatment of the DISH do not exist. This article aims to analyze the available literature concerning the rehabilitation treatment in patients affected by DISH. Materials and methods. Until July 2023, PubMed, PEDro, Scopus and Google Scholar were accessed, with no time constraints. Results. The literature available is poor, but the authors of the selected studies suggest programs based on therapeutic exercise, manual therapy, postural education, instrumental physical therapy. The discrepancy between the results obtained in case report and in RCT and cohort study, may express the need of a personalized treatment, since the characteristic of the pathology are variable depending on the localization of the hyperostosis. The rehabilitation strategies just proposed may be investigated in order to create a therapeutic path for DISH patients. Conclusions. Patients affected by DISH may cope with conditions of severe disability, caused by stiffness, pain, respiratory and dysphagic symptoms. The physiotherapy program should be based on stretching and mobility exercises to avoid pain and stiffness. This can be seen as the starting point, so that in the future this pathology might be more researched and easily diagnosed, in order to create useful guidelines and to better manage this less-known clinical condition.

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A case of cervical OPLL and DISH mimicking stroke

Cited by 2 publications

References 8 publications

Evidence for a genetic contribution to the ossification of spinal ligaments in Ossification of Posterior Longitudinal Ligament and Diffuse idiopathic skeletal hyperostosis: A narrative review

Evidence for a genetic contribution to the ossification of spinal ligaments in Ossification of Posterior Longitudinal Ligament and Diffuse idiopathic skeletal hyperostosis: A narrative review

The Diffuse Idiopathic Skeletal Hyperostosis (DISH): A Literature Review on the Rehabilitation Treatment

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