A case of classical Kawasaki disease with severe acute respiratory syndrome coronavirus 2 infection in Japan

Advances in understanding Kawasaki disease‐related immuno‐inflammatory response and vascular endothelial dysfunction

“…However, patients with MIS‐C have a shorter duration of fever and are more likely to develop myalgia, gastrointestinal symptoms (e.g., abdominal pain and diarrhea), nervous system damage, and signs of shock. 50 , 51 Additionally, patients with MIS‐C have greater risks of ventricular dysfunction and decreased cardiac output. 52 Second, similar to patients with KD, patients with MIS‐C have significantly increased levels of inflammatory markers (e.g., white blood cell count, erythrocyte sedimentation rate, C‐reactive protein, and procalcitonin), along with coagulation abnormalities (e.g., prolonged prothrombin time and elevated d‐dimer level), liver function abnormalities, and other laboratory findings indicative of disease.…”

“…First, in terms of clinical manifestations, patients with MIS‐C may have prolonged fever, rash, strawberry tongue, systemic vasculitis, and coronary aneurysm formation; these are similar to symptoms in patients with KD. However, patients with MIS‐C have a shorter duration of fever and are more likely to develop myalgia, gastrointestinal symptoms (e.g., abdominal pain and diarrhea), nervous system damage, and signs of shock 50,51 . Additionally, patients with MIS‐C have greater risks of ventricular dysfunction and decreased cardiac output 52 .…”