The patient was a 77-year-old woman who visited her local clinic in May 2023 to begin treatment for hypertension. A chest X-ray revealed a nodular shadow in the right lung, and she was referred to our hospital in June. As a result of further examination, in addition to ascending colon cancer with metastatic lung cancer, UICC(#8) Stage IVA, right renal cell carcinoma, UICC(#8) Stage I, was diagnosed, indicating multiple cancers. In August, laparoscope-assisted right hemicolectomy and right nephrectomy were performed. The renal cancer was a histological type of clear cell renal cell carcinoma with a maximum diameter of 31 mm. As noted, a metastatic lesion of the ascending colon cancer was found within this clear cell renal cell carcinoma. After systemic chemotherapy for metastatic lung cancer that was derived from the ascending colon cancer, right lower lobectomy under video-assisted thoracoscopic surgery was performed in December. At the time of writing, the patient is uneventful with no evidence of recurrence. Tumor-to-tumor metastasis is a rare phenomenon in which one tumor metastasizes to another tumor in either synchronous or metachronous multiple cancers. Here, we report this case of ascending colon cancer with tumor-to-tumor metastasis to renal cell carcinoma, including a review of the literature.