A Case of Community-Acquired Pneumonia Caused by Multidrug-Resistant <i>Acinetobacter baumannii</i> in Korea

Son, Young Woong; Jung, In Young; Ahn, Mi Young; Jeon, Yong Duk; Ann, Hea Won; Ahn, Jin Young; Ku, Nam Su; Han, Sanghoon; Choi, Jun Yong; Song, Young Goo; Kim, June Myung

doi:10.3947/ic.2017.49.4.297

Cited by 11 publications

(10 citation statements)

References 17 publications

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“…Acinetobacter baumannii is a well-recognized pathogen for nosocomial pneumonia but it is now being increasingly reported as a cause for community acquired pneumonia [ 5 ]. Acinetobacter baumannii associated CAP has been reported from countries in tropical or subtropical regions such as Australasia, Asia and Middle East [ 2 , 6 ]. Despite higher incidence in warm climate countries, there have been reported cases in North America as well [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is associated with patients requiring prolonged mechanical ventilation, underlying lung diseases, prior exposure to broad spectrum antibiotics and recent major surgery. There have been case reports of community acquired Acinetobacter baumannii [ 2 , 3 ]. Community acquired acinetobacter infection progresses more rapidly and is associated with a higher mortality compared to hospital acquired acinetobacter infection [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Community acquired multi drug resistant (MDR) Acinetobacter baumannii pneumonia in Malaysia – A case report

Mohd

Nesam

Kamaruzaman

et al. 2018

Respiratory Medicine Case Reports

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Acinetobacter baumannii is an aerobic Gram-negative coccobacillus that is associated with hospital acquired pneumonia. There is increased reporting of emergent cases of community acquired multidrug resistance (MDR) acinetobacter associated with a higher mortality due to antibiotic resistance. Community acquired MDR acinetobacter pneumonia has not been reported in Malaysia. Here we report a case of a 19-year-old army officer who presented with fever and respiratory symptoms for 5 days. He had no known medical illness before and no history of hospitalization. Upon arrival, he was in septicaemic shock, requiring invasive ventilator support and renal replacement therapy in intensive care unit. Chest radiograph showed bilateral lung consolidations and bronchoscopy revealed haemoserous and greenish bronchiole secretion. He was treated with broad spectrum antibiotics and oseltamivir. Unfortunately he died on day 3 of hospital admission. His bronchial lavage culture came back positive for MDR Acinetobacter baumannii. This case illustrates that clinicians need to be aware that MDR Acinetobacter baumannii can cause severe community acquired pneumonia. We may need to consider this diagnosis in patients who do not respond to standard therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Community acquired multi drug resistant (MDR) Acinetobacter baumannii pneumonia in Malaysia – A case report

Mohd

Nesam

Kamaruzaman

et al. 2018

Respiratory Medicine Case Reports

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“…In the aforementioned case, we are observing a rare condition of MDR polymicrobial bacteremia and sepsis, which had been caused by multiple pathogens, namely, P. aeruginosa, P. putida, A. baumannii, and K. pneumonia among which A. baumannii is a rare causative organism [10,11].…”

Section: Discussionmentioning

confidence: 99%

“…Antibiotic resistance is a global concern since new resistance mechanisms are appearing and spreading globally, minimizing our ability to treat common infectious diseases, thereby leading to prolonged illness, disability, and death [9]. Hence, hereby, we report a 73-year-old male patient with the complaints of breathlessness, cough with expectorations, vomiting, loose stools, and altered sensorium due to rare condition of MDR polymicrobial bacteremia and sepsis caused by rare pathogens, such as Acinetobacter baumannii so as to make an awareness regarding jeopardy of antibiotic-resistance and its consequences [10,11].…”

Section: Introductionmentioning

confidence: 99%

Multidrug-Resistant Polymicrobial Bacteremia and Sepsis: A Rare Case Report

Nia

Modaresahmadi

Thirumoorthi

et al. 2018

Asian J Pharm Clin Res

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Antibiotic-resistance is currently a serious threatening factor to global public health that needs a universal action by all government sectors and societies. Here, we report an aggressive case of multidrug-resistant (MDR) polymicrobial bacteremia and sepsis. A 73-year-old male patient was admitted to a tertiary hospital with the complaints of breathlessness, cough with expectorations, vomiting, loose stools, and altered sensorium due to polymicrobial bacteremia and sepsis, which was found to be antibiotic resistant. Blood culture reports showed Pseudomonas aeruginosa and Pseudomonas putida, and sputum culture showed Acinetobacter baumannii and Klebsiella pneumonia. However, according to the culture sensitivity test reports, the organisms were resistant to almost all antibiotics and different antibiotics were tried. On the last day of hospitalization, the patient started desaturation and developed bradycardia and after sometimes cardiac arrest. In spite of continuous cardiopulmonary resuscitation, the patient could not be resuscitated and declared to be dead. The patient was finally diagnosed with MDR polymicrobial bacteremia and sepsis, chronic obstructive pulmonary disease with cor pulmonale, colitis, diabetes mellitus, hypertension, and respiratory acidosis. Although polymicrobial bacteremia and sepsis are rare, awareness of such conditions and of the rare causative pathogens, such as A. baumannii, especially in patients with comorbidities, will help treat the patients with bacteremia and sepsis.

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“…Although it is still considered rare, community-acquired A. baumannii infections have been reported primarily in equatorial and sub-equatorial regions [ 4 , 5 ]. Recently, an increase in community-acquired Acinetobacter infections is being reported [ 6 , 7 , 8 ]. Health settings-acquired A. baumannii showed higher resistance to antibacterial drugs than community-acquired pathogens, despite these mortality rates still being very high (64%) [ 5 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Antibiogram, Prevalence of OXA Carbapenemase Encoding Genes, and RAPD-Genotyping of Multidrug-Resistant Acinetobacter baumannii Incriminated in Hidden Community-Acquired Infections

et al. 2020

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Acinetobacter spp. has gained fame from their ability to resist difficult conditions and their constant development of antimicrobial resistance. This study aimed to investigate the prevalence, susceptibility testing, OXA carbapenemase-encoding genes, and RAPD-genotyping of multidrug resistant Acinetobacter baumannii incriminated in hidden community-acquired infections in Egypt. The antimicrobial susceptibility testing was assessed phenotypically using Kirby–Bauer disk diffusion method. Also, Modified-Hodge test (MHT) was carried out to detect the carbapenemases production. Multiplex-PCR was used to detect the carbapenemase-encoding genes. Furthermore, the genetic relationship among the isolated strains was investigated using RAPD fingerprinting. The bacteriological examination revealed that, out of 200 Gram-negative non-fermentative isolates, 44 (22%) were identified phenotypically and biochemically as Acinetobacter spp. and 23 (11.5%) were molecularly confirmed as A.baumannii. The retrieved A.baumannii strains were isolated from urine (69%), sputum (22%), and cerebrospinal fluid (csf) (9%). The isolated A. baumannii strains exhibited multidrug resistance and the production rates of carbapenemases were 56.5, 60.9, and 78.3% with meropenem, imipenem, and ertapenem disks, respectively. The blaOXA-24-like genes were the most predominant among the tested strains (65.2%), followed by blaOXA-23 (30.4%) and blaOXA-58 (17.4%), in addition, the examined strains are harbored IMP, VIM, and NDM genes with prevalence of 60.9, 43.5, and 13%, respectively, while KPC and GES genes were not detected. RAPD-PCR revealed that the examined strains are clustered into 11 different genotypes at ≥90% similarity. Briefly, to the best of our knowledge, this study is the first report concerning community-associated A. baumannii infections in Egypt. The high prevalence of hidden multidrug-resistant (MDR) and extensively drug-resistant (XDR) A.baumannii strains associated with non-hospitalized patients raises an alarm for healthcare authorities to set strict standards to control the spread of such pathogens with high rates of morbidity and mortality.

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A Case of Community-Acquired Pneumonia Caused by Multidrug-Resistant Acinetobacter baumannii in Korea

Cited by 11 publications

References 17 publications

Community acquired multi drug resistant (MDR) Acinetobacter baumannii pneumonia in Malaysia – A case report

Community acquired multi drug resistant (MDR) Acinetobacter baumannii pneumonia in Malaysia – A case report

Multidrug-Resistant Polymicrobial Bacteremia and Sepsis: A Rare Case Report

Antibiogram, Prevalence of OXA Carbapenemase Encoding Genes, and RAPD-Genotyping of Multidrug-Resistant Acinetobacter baumannii Incriminated in Hidden Community-Acquired Infections

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