A Case of Congenital Leukemia Cutis

Choi, Ji Hoon; Lee, Hee Bong; Park, Chun Wook; Lee, Cheol Heon

doi:10.5021/ad.2009.21.1.66

Cited by 14 publications

(18 citation statements)

References 17 publications

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“…It remains unclear why some neonates with leukaemia develop cutaneous nodules and others have no cutaneous presentation. There is an association between leukaemia and maternal exposure to radiation, illicit drug use, dietary exposure to bioflavonoid and inherited conditions such as Down syndrome, neurofibromatosis, Bloom's syndrome and Fanconi's anaemia . Why some patients never progress from aleukaemic leukaemia to leukaemia also remains unknown.…”

Section: Risk Factorsmentioning

confidence: 99%

Neonatal leukaemia cutis

Handler

Schwartz

2015

Acad Dermatol Venereol

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Neonatal leukaemia cutis is a significant neoplasm that may represent a cutaneous manifestation of systemic leukaemia, usually of myeloblastic type. Rarely, it may be or appear to be limited to skin, in which case it is called neonatal aleukaemic leukaemia cutis. By definition, it presents within the first 4 weeks of life and often has a 'blueberry muffin baby' appearance of magenta coloured nodules affecting almost any area of the skin, usually sparing mucous membranes, palms and soles. This clinical pattern is more commonly associated with neonatal infections such rubella and toxoplasmosis, and may be evident with other neonatal neoplasms such as neuroblastoma. Due to the morbidity associated with chemotherapy and reported cases of spontaneous remission without systemic progression in those with neonatal aleukaemic leukaemia cutis without 11q23 translocation, the authors not treating the child with chemotherapy, but to simply monitor for fading of the violaceous nodules, and watch for possible signs of systemic leukaemia.

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Section: Risk Factorsmentioning

confidence: 99%

Neonatal leukaemia cutis

Handler

Schwartz

2015

Acad Dermatol Venereol

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“…Unlike acute leukemia presentation in older children, lymphadenopathy is less frequent in neonates. In infants who present with leukemia after few weeks of birth symptoms are ill-defined in form of fever, diarrhea, failure to thrive with leukemia cutis seen less commonly in them as compared to the neonate with leukemia at birth where they present with leukemia cutis and respiratory distress [8]. Diagnosis of CL is supported by cellular morphology, cytochemistry, IPT by flow cytometry and chromosomal studies.…”

Section: Discussionmentioning

confidence: 94%

“…Acute lymphoblastic leukemia though common in older children is rare in neonates with incidence of about 10%. In cases of Down syndrome, TAM is a well-recognized entity which shows spontaneous regression and is also associated with chromosome 21 mosaicism or translocation involving chromosome 21 with an otherwise normal karyotype with no features of Down syndrome [8,11]. Acute leukemia in infants differs significantly from the leukemia in older children.…”

Section: Discussionmentioning

confidence: 99%

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Congenital Acute Leukemia: A Rare Hematological Malignancy

Tewari¹,

Mehta²,

Tewari³

2017

J Neonatal Biol

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“…Third, there should be absence of any other condition that might cause leukemoid reactions mimicking CL, such as, congenital infections (TORCH), hemolytic disease of the newborn (HDN), hereditary spherocytosis, twin to twin transfusion, other neoplastic infiltrates and TMD, a nonmalignant leukocytosis seen usually in neonates with Down syndrome [8,10]. Therefore, to perform accurate diagnosis, differential diagnosis is very important.…”

Section: Discussionmentioning

confidence: 99%

Congenital leukemia of fetus with acquiredAML1gene duplication

et al. 2014

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Congenital leukemia is very rare, and its prevalence according to recently published papers is from 1 to 5 per million live births. This can be often diagnosed in postpartum throughout bone marrow biopsy, showing abnormal proliferation of immature blasts and granulocytic precursors. Hepatosplenomegaly is the most common feature which is found during perinatal examinations, that diagnosing is difficult during perinatal period. Hepatosplenomegaly can occur not only in congenital leukemia but in many other cases such as infection which is the most common cause. In other words, congenital leukemia is the one of the rare causes of hepatosplenomegaly. However, this case shows the fetus with the features of hepatosplenomegaly during perinatal period and being diagnosed as congenital leukemia associated with acquired AML1 gene duplication in postpartum through bone marrow biopsy. Due to its rare instance, we are to describe the case with a review of literatures.

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A Case of Congenital Leukemia Cutis

Cited by 14 publications

References 17 publications

Neonatal leukaemia cutis

Neonatal leukaemia cutis

Congenital Acute Leukemia: A Rare Hematological Malignancy

Congenital leukemia of fetus with acquiredAML1gene duplication

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