A Case of COVID-19-Associated Focal Segmental Glomerulosclerosis

Abstract

This case report details a 43-year-old female diagnosed with the collapsing variant of focal segmental glomerulosclerosis (FSGS) post-infection with coronavirus disease 2019 . The patient contracted COVID-19 after returning from a trip to Florida and initially presented to the emergency department with gastrointestinal symptoms. Thereafter, the patient was diagnosed with COVID-19 and was admitted for acute kidney injury and worsening COVID-19 infection. FSGS is a glomerulopathy that consists of glomerular scarring that leads to nephrotic syndrome, secondary to podocyte effacement. FSGS has many causes, as well as distinct variants, but is noted to have an association with some viruses, most notably HIV and cytomegalovirus (CMV). Although the association between FSGS and HIV or CMV is well established, the evidence is minimal in regard to other viruses. This case report serves to highlight the potential association of COVID-19 with FSGS.

2012-2022 TRPC6 channel and podocyte research trends: A bibliometric study

“…The TRPC6 protein is a 6-times transmembrane protein composed of 931 amino acids. The small pore region between its 5th and 6th transmembrane proteins forms the cation channel [8.9] The podocytes are cross-linked with each other to form a finger-like cross-linked fence-like structure called the lacunar pore, which is covered with a 4-6 nm film called the lacunar membrane SD.Recent studies have shown that podocytes are one of the important cells that make up the glomerular basement membrane [10] ,and abnormalities in the morphology, number and function of podocytes caused by various injury factors can cause proteinuria and eventually lead to renal function impairment [11][12][13] .Podocytes likewise play an important role in renal diabetic neuropathy, and many studies have demonstrated that podocyte loss and death are the earliest glomerular manifestations of renal diabetes [14][15][16].…”