A Case of Cutaneous Injury Induced by the Subcutaneous Injection of Leuprolide Acetate.

Hirashima, Noriyuki; Shinogi, Taro; Sakashita, Nao; Narisawa, Yutaka

doi:10.2336/nishinihonhifu.63.384

Cited by 8 publications

(5 citation statements)

References 7 publications

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“…The size of the nodules induced by the 3‐month type was 4–5 cm, which was larger than that (2–3 cm) of those induced by the 1‐month type 7–12 . Histologically, foreign body giant cells containing round translucent microspheres were observed in many cases 8–10,12 …”

Section: Discussionmentioning

confidence: 82%

“…Although these local reactions had not been examined histologically, they were presumed to be granulomatous reactions. Nine patients with leuprorelin acetate granuloma have been reported, 5–12 of whom seven were Japanese 7–12 . All patients were being treated for prostate carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…Two formulations of depot leuprorelin acetate, the 1‐month (3·75 mg) and the 3‐month (11·25 mg) types, had been used. Four patients treated with the 1‐month type only had received two to 36 (average 13) injections before the development of a granulomatous reaction, 7–9 while three patients presented subcutaneous nodules soon after several injections of the 3‐month type which had been changed from the 1‐month type 10–12 . The size of the nodules induced by the 3‐month type was 4–5 cm, which was larger than that (2–3 cm) of those induced by the 1‐month type 7–12 .…”

Section: Discussionmentioning

confidence: 99%

“…Four patients treated with the 1‐month type only had received two to 36 (average 13) injections before the development of a granulomatous reaction, 7–9 while three patients presented subcutaneous nodules soon after several injections of the 3‐month type which had been changed from the 1‐month type 10–12 . The size of the nodules induced by the 3‐month type was 4–5 cm, which was larger than that (2–3 cm) of those induced by the 1‐month type 7–12 . Histologically, foreign body giant cells containing round translucent microspheres were observed in many cases 8–10,12 …”

Section: Discussionmentioning

confidence: 99%

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Leuprorelin acetate granulomas: case reports and review of the literature

et al. 2005

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Leuprorelin acetate, an agonist of gonadotropin-releasing hormone (GnRH), is indicated in the treatment of prostate cancer. Recently, depot formulations of leuprorelin acetate have been widely used. We report three patients who showed a granulomatous reaction after treatment using a leuprorelin acetate 3-month depot formulation. These patients presented with 5-6-cm subcutaneous nodules at injection sites, which developed after the depot type was changed from a 1-month to a 3-month formulation. Skin biopsy showed epithelioid cells and foreign body giant cells containing round, translucent microspheres which formed sarcoidal granulomas. Changing to other GnRH agonists resulted in no further problems. We have reviewed the previous reports of leuprorelin acetate-induced granuloma formation. The formation of such granulomas may be related to the polymers that allow slow release after injection, or leuprorelin acetate itself may be responsible. The depot injection methods using leuprorelin also seem to have a causal effect in granuloma formation. Dermatologists need to know that depot leuprorelin acetate may cause a granulomatous reaction which produces a subcutaneous nodule that might be misdiagnosed as a malignant tumour.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Leuprorelin acetate granulomas: case reports and review of the literature

et al. 2005

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“…In a published work search, 4–13 we found 29 reported cases of leuprorelin acetate‐related granuloma. Only two reports were from outside Japan 4,5 .…”

Section: Discussionmentioning

confidence: 99%

Granuloma caused by subcutaneous injection of leuprorelin acetate product: Case report and histopathological findings

O‐Uchi

Koyama

Miyata

et al. 2006

The Journal of Dermatology

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Leuprorelin acetate is a luteinizing hormone-releasing hormone (LH-RH) analog, which is used for chemical castration. Chemical castration treatment has an especially important role for prostate cancer. To ensure ongoing chemical castration, a novel sustained-action injection system using spherical microcapsules has been developed. We report a patient who had granuloma caused by administration of the 11.25 mg leuprorelin acetate product. Histological examination revealed many giant cells with vacuoles. On the basis of reported cases, these vacuoles are characteristic for the granuloma caused by leuprorelin acetate product. The vacuoles in the granuloma are the same size as the microcapsules, and their shape is almost spherical. We assume that the vacuoles in the granuloma are actually the microcapsules. We expect that there will be investigations regarding the procatarctic cause of granuloma formation.

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Gonadorelin

2006

Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions

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A Case of Cutaneous Injury Induced by the Subcutaneous Injection of Leuprolide Acetate.

Cited by 8 publications

References 7 publications

Leuprorelin acetate granulomas: case reports and review of the literature

Leuprorelin acetate granulomas: case reports and review of the literature

Granuloma caused by subcutaneous injection of leuprorelin acetate product: Case report and histopathological findings

Gonadorelin

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