A case of dedifferentiated liposarcoma of the descending colon

Nakayama, Shinnosuke; Matsumura, Kazuyoshi; Fukuda, Akira; Seno, Hiroshi

doi:10.1007/s12328-023-01762-5

Cited by 2 publications

(8 citation statements)

References 11 publications

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“…LPS comprises 20% of malignant mesenchymal tumors and is relatively normal among mesenchymal tumors, with the peak age of onset between 40 and 60 years. [ 10 ] DDL represents approximately 10% of all LPS and typically exhibits an atypical lipomatous tumor or WDL conversion to a non-liposarcoma component. [ 1 ] DDL commonest histologic presentation is a high-grade sarcoma that is much less aggressive than other types of high-grade pleomorphic sarcomas.…”

Section: Discussionmentioning

confidence: 99%

Synchronous occurrence of small cell lung cancer and primary rectal dedifferentiated liposarcoma with osteosarcomatous differentiation: A rare case report

Zheng,

Wu,

et al. 2023

Medicine

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Rationale: Rectal dedifferentiated liposarcoma (DDL) and DDL with osteosarcomatous differentiation both are extremely unwonted. In addition, there are no reports of simultaneous DDL with osteosarcoma differentiation with small cell lung cancer (SCLC) to date. Therefore, it is imperative to alert clinicians and pathologists to this extremely rare and instructive synchronous tumor. Patient concerns: The patient was a 63-year-old male who presented with intermittent hematochezia and a swelling in the anus. Irregular masses were found on computed tomography (CT) examinations of the chest and abdomen respectively. Diagnosis: The final diagnosis of synchronous occurrence of SCLC and primary rectal DDL with osteosarcomatous differentiation was established by radiological, histological, immunohistochemical and molecular findings. Interventions: The patient underwent a puncture biopsy of the right lung mass and a complete resection of the rectal mass. Outcomes: The patient abandoned treatment, and multiple SCLC metastases appeared multiple metastasis 8 months after the operation. In the end, he expired suddenly due to severe cerebral hemorrhage caused by brain SCLC metastasis. Lessons: DDL with osteosarcoma differentiation is infrequent, and its accurate diagnosis is based on morphology, immunohistochemistry and the necessary molecular tests. In rare cases, DDL occurs concurrently with other malignancies and and will be a challenge for pathologists and clinicians at this time. Accordingly, a comprehensive examination to identify possible synchronous tumors is very important in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Synchronous occurrence of small cell lung cancer and primary rectal dedifferentiated liposarcoma with osteosarcomatous differentiation: A rare case report

Zheng,

Wu,

et al. 2023

Medicine

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“…Caracteristicile generale ale pacienților cu LPC incluși în aceste studii sunt prezentate în tabelul 1. Cel mai mare număr de cazuri clinice publicate de LPC a fost din SUA -6(20.7%) [2,5,8,18,22,27], Japonia -5(17.2%) [12,13,21,28,30], Italia -4(13.8%) [4,10,24,25], Coreea de Sud -3(10.3%) [11,17,26], India -3(10.3%) [7,23,29] și Turcia -2(6.9 %) [14,15]. Vârsta medie a pacienților cu LPC a fost de 60.1±2.9 ani (de la 17 la 86 de ani), iar raportul dintre bărbați și femei 1:1.…”

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“…Manifestările clinice în LPC sunt nespecifice, caracterizate printr-un polimorfism de simptome și includ: dureri în abdomen sau în regiunea lombară [2,5,6,9,10,11,14,15,16,17,22,23,24,25,27 ], disconfort abdominal [3], mărirea în volum a abdomenului [12], diaree [3,14,28,30], scădere ponderală [3,9,10,25], anemie [3,7], sânge în scaun [ 5,7,8,18], masă abdominală palpabilă [2,3,6,7,9,11,12,17,20,23], constipație [9], flatulență [23]. Printre complicațiile LPC sunt descrise: hemoperitoneul [11], invaginația [4,7,13,19,…”

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“…Printre complicațiile LPC sunt descrise: hemoperitoneul [11], invaginația [4,7,13,19,22,26,29], ocluzia intestinală obstructivă [25], hemoragia în lumenul tractului gastrointestinal [5,8,27]. Determinarea markerelor tumorali (CEA, CA 125, CA 19.9, CA 72.4 și alfa-fetoproteina -AFP), în cadrul algoritmulului de diagnostic preoperator, a demonstrat nivelul lor normal, în limitele valorilor de referință în toate cazurile [6,9,10,11,12,14,15,17,27,29,30].…”

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“…Distribuția LPC în diferite părți ale colonului a fost următoarea: valva ileocecală -2(6.9%) cazuri [2,26], colon ascendent -12(41.4%) [3,6,8,10,11,12,13,17,20,21,22,23], colon transvers -4(13.8%) [14,15,27,29], colon descendent -7(24.1%) [5,7,9,16,25,28,30] și doar într-un caz tumora a fost localizată în cec [4], unghiul hepatic al colonului [24], colon sigmoid [19] și rect [18].…”

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