A Case of Deep Vein Thrombosis after Coronary Angiography in a Patient Using Antidepressants and Anxiolytics

Abstract

Deep vein thrombosis (DVT) is a rare but potentially serious complication of coronary angiography (CAG) affecting just under 5 in 10000 patients. Most of the cases regarding DVT after CAG reported in the literature were associated with procedure-related vascular complications or with risk factors for venous thromboembolism (VTE). Here, we describe the case of a 50-year-old woman during treatment for anxiety disorder, who developed significant DVT after CAG without a history of VTE and with no significant risk factors for VTE, which was treated with an anticoagulant. This case reminds us that clinicians should consider the possible occurrence of VTE after diagnostic CAG even in patients without significant risk factors.

Deep Vein Thrombosis after Femoral Arterial Access: Pathophysiologic and Therapeutic Challenges

“…Additionally, the age and relative immobility of the patient described in Case 1 represent at least two additional nonmechanical risk factors for DVT formation. In contrast, Case 2 represents only the second reported case of seemingly unprovoked DVT formation following LHC utilizing femoral arterial access [5]. In such “unprovoked” cases, we suspect a likely inadvertent venous compression during femoral arterial hemostasis as the mechanism for DVT formation.…”

“…Supporting this hypothesis is the evidence that DVTs in this setting arise almost universally in the proximal rather than distal lower extremity venous system, which is reflected in our two cases. Literature review demonstrates only one other case of distal DVT following LHC [5], suggesting a strong anatomical relationship between the sites of access, hemostasis, and subsequent thrombus formation.…”

A Case of Thrombophlebitis Caused by Carbamazepine

“…Recently, a case of deep vein thrombosis after coronary angiography in a patient using antidepressants and anxiolytics was reported. However, there was neither detailed description on the antidepressants and anxiolytics nor any analysis of the influence of these drugs on TP in this paper [13]. Several reports are now available on the biochemical and clinical effect of antipsychotic drugs on Venous Thromboembolism (VTE) [14].…”