A case of delayed metastatic melanoma to the stomach

Anandabaskaran, Sulakchanan; Fewtrell, Miriam; Koçyiğit, İsmail; Prakoso, Emilia

doi:10.1111/imj.15122

Cited by 3 publications

(3 citation statements)

References 3 publications

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“…3,4 Melanoma involving the stomach is extremely rare, and the prognosis is generally poor. 5 In this case, the patient had a primary lesion in the occipital skin, progressed without sentinel lymph node metastasis but displayed mucosal lentiginous metastases in the stomach. For the patients who present with melena and had a history of melanoma, 5 melanoma to the upper gastrointestinal tract should be considered.…”

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confidence: 82%

“…Melanoma is the most common tumor to metastasize to the gastrointestinal tract, commonly affecting the small intestine, colon, and anorectum 3,4 . Melanoma involving the stomach is extremely rare, and the prognosis is generally poor 5 . In this case, the patient had a primary lesion in the occipital skin, progressed without sentinel lymph node metastasis but displayed mucosal lentiginous metastases in the stomach.…”

mentioning

confidence: 88%

“…In this case, the patient had a primary lesion in the occipital skin, progressed without sentinel lymph node metastasis but displayed mucosal lentiginous metastases in the stomach. For the patients who present with melena and had a history of melanoma, 5 melanoma to the upper gastrointestinal tract should be considered 6 . Increased 18 F-FDG uptake in the stomach can be caused by a variety of factors, including primary tumors, inflammation, physiological uptake, gastric melanoma metastasis, and other metastases 7,8 .…”

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confidence: 99%

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Melanin-Targeted PET Imaging With 18F-PFPN for Identifying Gastric Metastatic Melanoma

Zhang

Lan

2022

Clin Nucl Med

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A 47-year-old man, who had a history of occipital skin dissection for melanoma, underwent 18F-FDG and 18F-PFPN (a specific tracer targeting melanin) PET due to increased stomach discomfort and melena. In 18F-FDG and 18F-PFPN images, strong uptakes were both found in the thickened gastric wall, which was suspected as metastatic melanoma to the stomach. This was further confirmed by pathological biopsy of gastric tissue. Our case illustrated that melanin-targeted PET imaging could provide an effective method for searching the metastases of melanoma.

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confidence: 82%

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confidence: 88%

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confidence: 99%

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Melanin-Targeted PET Imaging With 18F-PFPN for Identifying Gastric Metastatic Melanoma

Zhang

Lan

2022

Clin Nucl Med

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The authors have requested that this preprint be removed from Research Square

Liu

Peng

Gao

2023

Preprint

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Background: Primary malignant melanoma (MM) of external ear accounts for a low proportion of cutaneous MM and its incidence in non-white females is very low. The stomach is a rare metastatic site for MM. Cases of gastric metastasis of external ear MM are extremely rare, of which the gene alterations and mechanism of metastasis are poorly understood. Case presentation: We report a 58-year-old Asian female patient who had a mass on the left auricle for 5 years and was diagnosed as nodular MM with BRAF V600E mutation after surgical resection. Postoperative metastases to the stomach and descending duodenum appeared one year later. After 11 months of BRAF-targeted therapy and immunotherapy, the patient was resistant to the drug and then died of systemic metastases to the brain, lungs, liver, left adrenal gland, and peritoneum. In addition to BRAF mutation, genetic testing showed aberrations of MYB, p16, MYC, and PTEN in this case. Conclusion: The clinical characteristics of external ear MM and gastric metastatic MM were summarized by retrospective study of the literature, respectively. Immunohistochemical staining is critical in the diagnosis of gastric metastasis from external ear MM, which often requires a multidisciplinary treatment approach, including surgery, targeted therapy and immunotherapy. We would like to provide some genetic information about the rare disease and discuss the appropriate treatment strategies for it. The present study suggested that the size of surgical margin, histological type of tumor and number of genetic aberrations may be closely associated with the metastasis potential, therapeutic efficacy and patient outcome.

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Gastric metastasis from nodular malignant melanoma of the auricle with multigene aberrations: A rare case report and literature review

Liu¹,

Pan

Gao

2023

Oncol Lett

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Primary malignant melanoma (MM) of the external ear accounts for a low proportion of cases of cutaneous MM, and its incidence in non-white women is very low. The stomach is a rare metastatic site for MM. Gastric metastasis of MM of the external ear is extremely rare, and the associated gene alterations and mechanisms are poorly understood. The present report describes the case of a 58-year-old Asian woman who had a mass on the left auricle for 5 years and was diagnosed with nodular MM with the BRAF V600E mutation after surgical resection. Postoperative metastases to the stomach and descending duodenum appeared 1 year after resection. After 11 months of BRAF-targeted therapy and immunotherapy, the patient developed drug resistance and died from systemic metastases to the brain, lungs, liver, left adrenal gland and peritoneum. Genetic testing revealed additional aberrations in MYB, p16, MYC and PTEN. The clinical characteristics of MM of the external ear and gastric metastatic MM were also summarized through a retrospective literature review. Immunohistochemical staining is critical in the diagnosis of gastric metastasis from MM of the external ear. This disease often requires a multidisciplinary treatment approach, including surgery, targeted therapy and immunotherapy. The present study provides some genetic information about this rare disease and discusses appropriate treatment strategies. The findings of the present study suggests that the surgical margin size, tumor histological type and number of genetic aberrations may be closely associated with metastasis potential, therapeutic efficacy and patient outcome.

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A case of delayed metastatic melanoma to the stomach

Cited by 3 publications

References 3 publications

Melanin-Targeted PET Imaging With 18F-PFPN for Identifying Gastric Metastatic Melanoma

Melanin-Targeted PET Imaging With 18F-PFPN for Identifying Gastric Metastatic Melanoma

The authors have requested that this preprint be removed from Research Square

Gastric metastasis from nodular malignant melanoma of the auricle with multigene aberrations: A rare case report and literature review

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