A case of dementia with Lewy bodies and Hashimoto encephalopathy successfully treated with immunotherapy

Ikawa, Fumiaki; Sumi, Natalia J.; Nishikawa, Tomokazu; Makino, Hírofumi; Miyachi, Takafumi

doi:10.5692/clinicalneurol.cn-001204

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…Moreover, patients with NAE-associated HE sometimes show cognitive impairments similar to dementia with Lewy bodies or AD. 38,39 Patients with HE rarely presented with CJD-like symptoms,…”

Section: Other Anti-nae Antibody-associated Psychosis (Including Deme...mentioning

confidence: 99%

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Expanding clinical spectrum from Hashimoto's encephalopathy to anti‐NAE antibody‐associated disorders (NAEAD)

Matsunaga,

Ikawa,

Yoneda

2023

Clinical & Exp Neuroim

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Using proteomic analysis, we identified anti‐NAE antibodies (autoantibodies against NH2‐terminal of alpha‐enolase) as a diagnostic marker for Hashimoto's encephalopathy (HE). As cases of HE with serum anti‐NAE antibodies accumulated, the clinical spectrum of HE with anti‐NAE antibodies became expanded. In addition, it is now known that antibodies can be detected in other diseases that differ from conventional HE. We recently reported the detection of anti‐NAE antibodies in patients with a clinical diagnosis of multiple system atrophy or corticobasal syndrome. These findings suggest that anti‐NAE antibodies indicate an immune mechanism in the pathogenesis of neurodegenerative diseases. We propose a novel disease concept for anti‐NAE antibody‐associated disorders (NAEAD). The clinical spectrum of NAEAD is not limited to HE but is a broad spectrum that partially shares several autoimmune neurological diseases, including autoimmune acute encephalopathy, autoimmune cerebellar ataxia, and autoimmune psychosis, and even extends to immune‐associated neurodegenerative diseases.

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“…Moreover, patients with NAE-associated HE sometimes show cognitive impairments similar to dementia with Lewy bodies or AD. 38,39 Patients with HE rarely presented with CJD-like symptoms,…”

Section: Other Anti-nae Antibody-associated Psychosis (Including Deme...mentioning

confidence: 99%

“…Thus, anti‐NAE antibodies also seem to be partly involved in the pathogenesis of autoimmune psychosis. Moreover, patients with NAE‐associated HE sometimes show cognitive impairments similar to dementia with Lewy bodies or AD 38,39 …”

Section: Clinical Profiles Of Anti‐nae Antibody‐associated Hementioning

confidence: 99%