A case of desmoplastic trichoepithelioma with ossification

Wada, Makoto; Hanada, Keiji; Kanehisa, Fuminao; Asai, Jun; Takenaka, Hideya; Katoh, Norito

doi:10.4103/0019-5154.108112

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…Aberrant ossification has been reported in other lesions associated with physiological or nonphysiological keratins: seborrheic keratosis, [10] actinic keratosis, [11] keratoacanthoma, [12] acne vulgaris, [13] epidermal cyst, [14] trichilemmal cyst, [15] desmoplastic trichoepithelioma, [16] chondroid syringoma, [17] and tumors histopathologically exhibiting shadow cells such as craniopharyngioma [18] and calcifying odontogenic cyst [19] . This phenomenon has also been observed in keratin-expressing tumors, including thymoma, [20] sarcoma, [21] and carcinomas such as basal cell carcinoma, [22] squamous cell carcinoma, [23] papillary thyroid carcinoma, [24] and rectal carcinoma [25] .…”

Section: Discussionmentioning

confidence: 99%

Ossifying pilomatricoma and a novel hypothesis for its pathogenesis

et al. 2022

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Rationale:Pilomatricoma is a benign skin appendageal tumor derived from hair follicle matrix cells that commonly affects the head, neck, and upper extremities of the pediatric population. Since the original tumor description, diverse variants have been reported in the literature. Pilomatricoma with florid osseous metaplasia is described as an ossifying pilomatricoma and is recognized as a distinct variant of this benign tumor. However, the pathogenesis of this variant remains unclear. In this study, we present an uncommon case of ossifying pilomatricoma and address the pathogenesis of metaplastic ossification through a comprehensive literature review.Patient concerns:A 14-year-old boy presented with an asymptomatic protuberant mass in the preauricular region.Diagnosis:Based on its clinicopathological features, we diagnosed the lesion as an ossifying pilomatricoma.Interventions and outcomes:The lesion was surgically removed under local anesthesia. The postoperative course was uneventful during the 6-month postoperative follow-up.Lessons:We suggest that metaplastic ossification in ossifying pilomatricoma represents another feature of foreign body reaction to keratinous materials containing shadow cells in old lesions and a walling-off phenomenon to prevent exposure of surrounding tissues to keratinous materials.

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Section: Discussionmentioning

confidence: 99%

Ossifying pilomatricoma and a novel hypothesis for its pathogenesis

et al. 2022

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“…Other features that have been reported include granulomatous reactions from cyst rupture, calcification, absence of solar elastosis below the lesion, pseudoepitheliomatous hyperplasia, tumor attachment to the epidermis, and focal bone formation. [ 2 3 4 5 6 ] Perineural involvement may occur and could result in misdiagnosis of a malignant neoplasm. [ 7 8 ] Because DTE may differentiate toward various parts of the folliculosebaceous apocrine unit, immunohistochemistry staining for glandular structures may be focally positive.…”

Section: Discussionmentioning

confidence: 99%

A firm plaque on the cheek

Torres

Elston

Polley³

et al. 2016

Indian Dermatol Online J

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“…Columnar trichoblastoma, also known as desmoplastic trichoepithelioma, presents as a symmetrical, wellcircumscribed papule with a central depression. Histopathologically, columnar trichoblastoma is composed of narrow strands of epithelial basaloid cells, several horn cysts, granulomatous reaction, calcification, and dense fibrous stroma (Figure 5) [5,6,37,38]. The lesion is typically restricted to the papillary dermis and the upper portions of the reticular dermis [32,39].…”

Section: Columnar Trichoblastomamentioning

confidence: 99%

Trichoblastomas Mimicking Basal Cell Carcinoma: The Importance of Identification and Differentiation

Patel

Nawrocki

Hinther

et al. 2020

Cureus

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Trichoblastoma is a rare, slow-growing, benign cutaneous tumor derived from follicular germinative cells. Trichoblastoma commonly appears as an asymptomatic, symmetrical, well-circumscribed, skin-colored to brown or blue-black papule or nodule. It may appear clinically and histologically similar to basal cell carcinoma, making its diagnosis challenging. Even on dermoscopy, it is challenging to differentiate trichoblastoma from basal cell carcinoma. In practice, it is important to differentiate the two, because the choice of treatment and resulting prognosis differ between the lesions. Surgical biopsy to analyze histopathological and immunohistochemical differences is the gold standard for diagnosing and differentiating trichoblastoma from basal cell carcinoma. Trichoblastoma typically has a favorable prognosis, with a low incidence of recurrence, progression or association with malignancy. This paper provides a review of the epidemiology, clinical presentation, dermoscopy, histology, immunochemistry, treatment, and prognosis of trichoblastoma.

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A case of desmoplastic trichoepithelioma with ossification

Cited by 3 publications

References 7 publications

Ossifying pilomatricoma and a novel hypothesis for its pathogenesis

Ossifying pilomatricoma and a novel hypothesis for its pathogenesis

A firm plaque on the cheek

Trichoblastomas Mimicking Basal Cell Carcinoma: The Importance of Identification and Differentiation

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