A Case of Development of Sarcoidosis During Tumor Necrosis Factor-alpha Antagonist Therapy

Park, Soo Yuck; Kim, Eun Kyoung; Hwang, Deokbi; Lee, Kang Won; Paik, Seung Sam; Jung, Kwan Ho; Kim, So Yeon

doi:10.4078/jrd.2011.18.1.41

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2016

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“…In Korea, two cases of sarcoidosis were earlier reported: adalimumab-induced disease in a patient with rheumatoid arthritis [7] and etanercept-induced sarcoidosis in a patient with AS [8]. A literature search identified 45 cases of sarcoidosis (including Korean cases) [5,[7][8][9][10] that developed during anti-TNF therapy. The mean patient age was 47.53 years, and the male-to-female ratio was 2:3.…”

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confidence: 99%

A Case of Sarcoidosis That Improved upon Discontinuation of Etanercept

Kang

Ahn

et al. 2016

J Rheum Dis

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A 31-year-old man who had been prescribed etanercept over a 3-year period for treatment of ankylosing spondylitis presented with newly developed dry cough, chills, myalgia, and weight loss. Chest computed tomography showed multiple reticulonodular pulmonary infiltrates and bilateral mediastinal, hilar, and peribronchial lymphadenopathy. Biopsy of a paratracheal lymph node revealed chronic granulomatous inflammation without necrosis, and the serum angiotensin-converting enzyme level was elevated. Sarcoidosis was diagnosed. His laboratory and radiological findings, and clinical symptoms improved only after discontinuation of etanercept without treatment. Although etanercept-induced sarcoidosis is rare, this case report suggests that sarcoidosis should be considered in the differential diagnosis of patients treated with the tumor necrosis factor inhibitor. (J Rheum Dis 2016;23:187-192)

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