A Case of Digital Cutaneous Melanocytic Tumor With CRTC1::TRIM11 Fusion

Abstract

A cutaneous melanocytic tumor with CRTC1::TRIM11 fusion (CMTCT) was recently described as a novel superficial tumor with melanocytic differentiation and harboring a unique in-frame translocation, CRTC1::TRIM11. This emerging entity can occur at any age and is known to be a low-grade malignant neoplasm with limited follow-up data. There are no available guidelines for the management and treatment of this tumor. This neoplasm has been found in the extremities, head and neck, and trunk. Here, we present the first case occurring on acral digital skin. This case contributes to the growing knowledge surrounding this newly described entity.

CRTC1::TRIM11 cutaneous tumor: An update with local recurrence and lung metastasis in a pediatric patient

“…All but one case displayed indolent behavior. Since then, 34 new cases have been published 3–5 . Although 21 of these patients have remained disease free with no evidence of recurrence after a median follow‐up of 37 months (range: 12–168 months), three cases displayed aggressive behavior.…”

“…Another case had multiple positive regional lymph node metastases. Notably, neither of these tumors displayed any defining features that would otherwise predict an aggressive course 3,4 . However, a 30‐year‐old man with CTCT on the hip harboring TERT promoter variant developed regional inguinal lymph node and pulmonary metastases at 18 and 36 months, respectively 5 …”

“…Since then, 34 new cases have been published. [3][4][5] Although 21 of these patients have remained disease free with no evidence of recurrence after a median follow-up of 37 months (range: 12-168 months), three cases displayed aggressive behavior. One completely excised lesion had local recurrence at 6 months after initial diagnosis, and the patient subsequently remained disease free following re-excision after 30 months of follow-up.…”

“…Notably, neither of these tumors displayed any defining features that would otherwise predict an aggressive course. 3,4 However, a 30-year-old man with CTCT on the hip harboring TERT promoter variant developed regional inguinal lymph node and pulmonary metastases at 18 and 36 months, respectively. 5 We now report that our case developed local recurrence and lung metastasis despite wide local excision with 1.5 cm margins of the original tumor (0.5 cm margins initially, followed by 1 cm margins on re-excision).…”

TRIM11 promotes cell proliferation of non‐small cell lung cancer through the inhibition of ferroptosis by AMPK

“…High expression of TRIM11 was observed in advanced stage gliomas, while low expression was associated with poor differentiation and favorable prognosis 21 . Additionally, TRIM11 can activate MAPK or PI3K/AKT signaling pathways to promote tumor cell proliferation, invasion, and migration 22 . Shang et al identified that TRIM11 suppresses ferritinophagy in pancreatic ductal adenocarcinoma 23 .…”