A case of disseminated histoplasmosis mimicking miliary tuberculosis

Abstract

A 50-year-old immunocompromised female presented with a 10-day history of fever and dyspnea. She had recent VFR travel to Vietnam and had lived in Calgary, Alberta for 20-years. Investigations revealed bicytopenia, elevated cholestatic enzymes, and a miliary nodular pattern on chest imaging. She was diagnosed with a disseminated fungal infection.

Hemophagocytic lymphohistiocytosis secondary to histoplasmosis: A case report in a patient with AIDS and recent SARS-CoV-2 infection and minireview

“…Moreover, because of its overlapping clinical-radiological and histological characteristics, tuberculosis is the leading differential diagnosis in our geographic region, particularly in immunocompromised individuals. Comparable clinical characteristics and immunopathogenesis characterize the two disorders, and infections that have lasting dormancy for an extended period may be reawakened due to a weaker immune system [ 4 , 12 , 13 ].…”