A Case of Donor Cell-derived Diffuse Large B-cell Lymphoma after 24-year Remission of Acute Myeloid Leukemia Followed by Successful Allogeneic Bone Marrow Transplantation

Kanamori, Takashi; Kayukawa, Satoshi; Kikuchi, Takaki; Totani, Haruhito; Miyamura, Koichi; Ito, Masafumi; Kataoka, Takae

doi:10.2169/naika.102.721

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2014

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“…These procedures do not always prove sufficient to protect a transplant recipient from an unexpected rare event, as we have presented. Similar complications have been infrequently reported, mainly cases of chronic lymphocytic leukemia .…”

Section: Discussionsupporting

confidence: 67%

Multiorgan transplantation from a deceased donor with intravascular diffuse large B‐cell lymphoma: transmission of the disease and results of treatment

Dziewanowski¹,

Drozd²,

Parczewski

et al. 2014

Clinical Transplantation

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This report presents the transplantation of two kidneys and the liver from a deceased donor with suspected autoimmune encephalomeningitis (ADEM). Due to an atypical post-transplantation clinical course, the transplanted kidneys were biopsied and this disclosed diffuse large B-cell (DLBC) lymphoma of the intravascular type in each kidney. The same malignancy was found in the postmortem donor brain examination. The renal allografts from the two recipients were removed: despite every effort, one patient died, while chemotherapy was successful in the second. No malignancy was observed in the liver transplant recipient, who received prophylactic chemotherapy. These cases highlight the occasional failure of organ donor disease screening and the consequent unforeseen complications.

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Section: Discussionsupporting

confidence: 67%