A case of donor-derived granulocytic sarcoma after allogeneic hematopoietic stem cell transplantation

Jeong, Seong Hyun; Han, Jae Ho; Jeong, Sun Young; Kang, Seok Yun; Lee, Hyun Woo; Choi, Jin-Hyuk; Park, Joon Seong

doi:10.5045/kjh.2010.45.1.70

Cited by 7 publications

(2 citation statements)

References 14 publications

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“…23 The same report included an additional number of 22 cases that were identified from reported cases in the literature, and 20 (92%) of those cases were positive for CBFB-MYH11 fusion protein. 23 The current review of the literature identified 11 additional cases of intestinal myeloid sarcoma 17,[24][25][26][27][28][29][30][31][32][33] that evaluated for genetic abnormalities by either cytogenetic or molecular testing, and the most common chromosomal rearrangement was inv (16) in 2).…”

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confidence: 99%

Gastrointestinal Myeloid Sarcoma a Case Presentation and Critical Review of the Literature

Kheirkhah

Avila-Rodriguez

Radzik

et al. 2021

Mediterr J Hematol Infect Dis

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Myeloid sarcomas can be detected in up to 30% of acute myeloid leukemia cases or occur de-novo without bone marrow involvement. The most frequent localization of myeloid sarcomas in the abdominal cavity is the small intestine, and gastric presentations are infrequent, frequently misdiagnosed, and a high level of suspicion should exist when the characteristic histomorphology features are present. The current review features a case report with gastric presentation of myeloid sarcoma in a patient with a diagnosis of acute myeloid leukemia with trisomy 8. In addition, a review of the literature of intestinal type myeloid sarcomas shows that less than 15% of these cases have been reported in the stomach. The most common molecular aberrancy detected in intestinal myeloid sarcomas is the fusion protein CBFB-MYH11. Review of several large studies demonstrates that the presence of myeloid sarcoma does not constitute an independent prognostic factor. The therapeutic approach will be tailored to the specific genetic abnormalities present, and systemic chemotherapy with hematopoietic stem cell transplant are the most efficient strategies.

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confidence: 99%

Gastrointestinal Myeloid Sarcoma a Case Presentation and Critical Review of the Literature

Kheirkhah

Avila-Rodriguez

Radzik

et al. 2021

Mediterr J Hematol Infect Dis

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“…Donor-derived granulocytic sarcoma has been reported after stem cell transplant very rarely. One reported case of a 35-year-old man was transplanted with HLA full matched sibling (sister) donor for normal karyotype AML [ 6 ]. Then, 57 months after his transplant the patient developed a granulocytic sarcoma of the duodenum while a bone marrow biopsy and aspiration showed normal hematopoiesis with full donor chirmerism.…”

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confidence: 99%