A case of ductal carcinoma with squamous differentiation in malignant phyllodes tumor

Sugie, Tomoharu; Takeuchi, Eiji; Kunishima, Fumihito; Yotsumoto, Fumiaki; Kono, Yasuhisa

doi:10.2325/jbcs.14.327

Cited by 36 publications

(22 citation statements)

References 19 publications

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“…In total, 16 patients were alive at the end of last follow-up. Distance metastasis occurred in the lung in 2 cases at 3 and 32 months subsequent to surgery, respectively (20,24). Similar to the current case, Kuo et al (19) and Parfitt et al (16) reported the combination of surgery, chemotherapy and radiotherapy for patients with lymph node metastasis who present breast carcinoma within PT.…”

Section: Discussionsupporting

confidence: 74%

“…Similar to the current case, Kuo et al (19) and Parfitt et al (16) reported the combination of surgery, chemotherapy and radiotherapy for patients with lymph node metastasis who present breast carcinoma within PT. In addition, 3 cases succumbed to the disease, 3, 40 and 108 months subsequent to surgery, respectively (20,24,25) (Table I).…”

Section: Discussionmentioning

confidence: 99%

“…As there is no standard adjuvant treatment strategy for this type of disease, a variety of systemic therapies were applied to the various cases. In total, 6 cases received chemotherapy with various regimens (16,(19)(20)(21)(22)(23), 5 cases received radiotherapy (13,16,18,20), and 4 cases received endocrine therapy, 3 of which received tamoxifen (1,16,21) and 1 received tamoxifen and goserelin (19). Patient outcomes were described in 19 cases.…”

Section: Discussionmentioning

confidence: 99%

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Invasive ductal carcinoma within borderline phyllodes tumor with lymph node metastases: A case report and review of the literature

Zhang

Guo

et al. 2016

Oncology Letters

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Abstract. Phyllodes tumor (PT) is a rare type of biphasic fibroepithelial neoplasm that may coexist with a breast tumor in rare cases. In the current study, a 52-year-old female presented with a left breast lump. Mammography and sonographic examination results suggested a diagnosis of malignant tumor. Histological analysis revealed a borderline PT with invasive ductal carcinoma (IDC) within the tumor. Due to the presence of a single micrometastasis in three of the sentinel lymph nodes, the patient underwent modified radical mastectomy. The excised tumor contained triple negative breast cancer; therefore, postoperative treatment included six cycles of chemotherapy and 25 cycles of radiotherapy. The patient exhibited no recurrence and no metastatic disease at the 23-month follow-up examination. Thus, the present study discussed the case of a female patient that presented with IDC within borderline PT and reviewed the literature on this rare type of neoplasm. Various types of breast carcinoma have been identified to coexist with PT in different masses; however, no standard therapeutic regimen has been established for the coexistence of PT and breast cancer in the same mass. The present study indicates that determination of an appropriate treatment strategy predominantly depends on the characteristics of the individual breast tumor.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Invasive ductal carcinoma within borderline phyllodes tumor with lymph node metastases: A case report and review of the literature

Zhang

Guo

et al. 2016

Oncology Letters

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“…- - 1 is mentioned above (27) and 1 developed lung metastasis and succumbed 10 months following surgery (14).…”

Section: Nomentioning

confidence: 99%

“…The patient received preoperative chemotherapy with FEC followed by PTX. However, no post-surgical chemotherapy was administered, and the patient succumbed to PT lung metastasis 40 months following surgery (27). Since no standard therapy for PT has been established, a variety of combinations of surgery, chemotherapy, endocrine therapy and/or RT are applied.…”

Section: Her2 Pgrmentioning

confidence: 99%

Ductal carcinoma in situ arising within a benign phyllodes tumor: A case report with a review of the literature

et al. 2010

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Abstract. Phyllodes tumor (PT) is a rare type of breast tumor that rarely occurs with breast carcinoma. This study evaluated a 53-year-old female patient with a benign PT with ductal carcinoma in situ (DCIS) within the tumor. A firm, painless, well-demarcated tumor measuring 4-5 cm was noted in the left breast. Over the course of the previous 14 years, the patient underwent excision of a breast tumor four times at the same site in the left breast. The pathological diagnosis of the first tumor was a fibroadenoma (FA), and those of the following three were benign PTs. The tumor was the 5th one noted over the course of the previous 14 years, following the previously recorded surgeries. A firm tumor with a diameter of 3.5 cm was located beneath the scar from the previous surgery, just above the nipple of the left breast. Mammography revealed a high-density irregularly shaped mass with a clear margin. An ultrasound showed low but heterogeneous echogenicity. A computed tomography scan revealed a well-defined enhanced tumor. These image examinations were compatible with recurrent PT. Fine-needle aspiration cytology revealed that the tumor was likely a benign FA. The patient underwent a partial mastectomy with a 1.0 cm margin from the tumor edge, and the firm, attached scar tissue was also resected. Macroscopic examination showed a hard elastic mass, which was encapsulated by thin fibrous tissue and which adhered firmly to the adjacent scar tissue. Microscopic examination showed a 5 mm in diameter DCIS of the cribiform type in a section of the PT epithelial component with an apparently benign stroma. The DCIS cells were strongly positive for estrogen and progesterone receptors, but HER2 expression was negative (score 0). The patient received local irradiation following surgery and no evidence of recurrence or metastasis was detected in the 2 years following surgery. This was a noteworthy case of a DCIS arising in benign PT. To the best of our knowledge, a total of 28 breast carcinomas were previously reported to arise in PT. In this case report, a female patient who presented with a PT was evaluated. A review of the literature is also discussed.

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Fibroepithelial Lesions (Phyllodes Tumor and Fibroadenoma) of the Breast

Tsang

Tse

2019

Practical Breast Pathology

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A case of ductal carcinoma with squamous differentiation in malignant phyllodes tumor

Cited by 36 publications

References 19 publications

Invasive ductal carcinoma within borderline phyllodes tumor with lymph node metastases: A case report and review of the literature

Invasive ductal carcinoma within borderline phyllodes tumor with lymph node metastases: A case report and review of the literature

Ductal carcinoma in situ arising within a benign phyllodes tumor: A case report with a review of the literature

Fibroepithelial Lesions (Phyllodes Tumor and Fibroadenoma) of the Breast

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