A case of eccrine epithelioma.

Periocular Microcystic Adnexal Carcinoma: A Case Report and a Major Review

“…Of patients with available information, most tumors presented as brown-to-reddish (5/18, 28%) 32,54,57,59,62 or pearly white-to-waxy (7/18, 39%) 8,24,33,40,52,58,68 nodules (37/68, 54%) 2,3,5,9,11,14–16,19,23–26,32,33,35,37,43,46,48,52,54,56,59,66,67,69 or plaques (20/68, 29%) 8,13,17,18,21,22,24,28,29,42,47,54,58,59,61–63,68 that were ill-defined, sclerotic, or indurated (20/51, 39%) 3,13,25,26,32,33,42,46,47,56,57,59,62,63,68 with firm consistency (19/51, 37%), 2,8,13,23,24,28,36,37,47,54,56,68 10 mm or greater in size (33/46, 72%). 3,6,11,13,14,17,18,24,25,29,35,37,42,47,49,51,52,…”

“…Patient management is summarized in Table 3. The initial intervention included simple excision in 47 of 93 (51%) patients, with margins reported as negative for carcinoma in 33 of 47 (70%), 2,5,13,21,22,26,33–35,42,44,45,47,52,53,59,60,68 positive in 7 of 47 (15%), 5,11,15,24,38,49 and not documented in 7 of 47 (15%) cases. 17,24,25,27,57,59 Excision with frozen section clearance of margins was performed in 8 of 93 (9%) patients.…”

“…Review of the literature identified 92 patients fulfilling the inclusion criteria for this study in addition to our current patient, for a total of 93 patients with MAC. 2,3,5,8,9,11–69 Patient demographics and presenting characteristics are summarized in Table 1.…”

“…Eighty-six of 93 (92%) tumors originated in the periocular skin, most commonly in the eyebrow (26/86, 30%) [12][13][14]17,18,20,22,23,[25][26][27]29,30,36,37,43,47,48,53,[59][60][61]67 followed by the lower eyelid (20/86, 23%). 2,8,11,13,32,33,35,39,40,49,54,56,58,59,62 Fifteen of 86 (17%) tumors involved more than 1 region. Primary orbital/periorbital involvement at presentation was reported in 11 of 86 (13%) patients, associated with diplopia in 3 patients.…”

“…5,13,24,42,44 Of 59 patients with known information, the median symptom duration was 3 years (average 7, range 0-50 years). Of patients with available information, most tumors presented as brown-to-reddish (5/18, 28%) 32,54,57,59,62 or pearly white-to-waxy (7/18, 39%) 8,24,33,40,52,58,68 nodules (37/68, 54%) 2,3,5,9,11,[14][15][16]19,[23][24][25][26]32,33,35,37,43,46,48,52,54,56,59,66,67,69 or plaques (20/68, 29%) 8,13,17,18,21,22,…”