A case of endocarditis of difficult diagnosis in dialysis: could “pest” friends be involved?

Malek-Marín, T; Arenas, María Dolores; Perdiguero, M; Salavert-Lletí, Miguel; Moledous, A; Cotilla, E; Gil, M T

doi:10.5414/cnp72405

Cited by 12 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The crude mortality rate for patients with A xylosoxidans endocarditis is high. More than 50% of the patients with A xylosoxidans endocarditis died (7)(8)(12)(13)(14)(15)(16). Five of the surviving patients, including our patient, required surgical resection of the infected tissue in addition to a prolonged course of antibiotics (9)(10)(11)16).…”

Section: Discussionmentioning

confidence: 87%

“…Bacteremia secondary to A xylosoxidans is uncommon, and the majority (1,3,4,21,31,35). In our review of other case reports, one patient had undergone a hematopoietic stem cell transplant (12), and four other patients had chronic underlying illnesses including diabetes, heart failure or dialysis-dependent renal failure (7,8,11,13). One patient was an intravenous drug user (9).…”

Section: Discussionmentioning

confidence: 91%

“…Clinical manifestations of Achromobacter endocarditis varied, but all patients presented with fever (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Polymicrobial endocarditis occurred in one patient (8%) and involved Candida species and A xylosoxidans (12).…”

Section: Discussionmentioning

confidence: 99%

“…Ten patients (77%), including the present one, had sufficient data available to determine a health care-associated relationship with the infection (7)(8)(9)12,(14)(15)(16)(17). Nosocomial infective endocarditis is defined as developing within 72 h after hospital admission or within eight weeks of an invasive procedure (36).…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Achromobacter species endocarditis: A Case Report and Literature Review

Derber

Elam

Forbes

et al. 2011

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

Endocarditis due to Achromobacter species is a rare, yet serious, endovascular infection. Achromobacter species infective endocarditis is associated with underlying immunodeficiencies or prosthetic heart valves and devices. A case of prosthetic pulmonary valve endocarditis secondary to Achromobacter xylosoxidans subspecies denitrificans is described in the present report. This life-threatening infection was successfully treated with combined valve replacement and prolonged antibiotic therapy. A Medline/PubMed literature review of Achromobacter endocarditis was also performed. Achromobacter species are an uncommon, yet important, cause of nosocomial endocarditis. Given the significant associated morbidity and mortality, along with a high degree of intrinsic antibiotic resistance, Achromobacter species infective endocarditis remains a clinical treatment challenge.

show abstract

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Achromobacter species endocarditis: A Case Report and Literature Review

Derber

Elam

Forbes

et al. 2011

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

show abstract

“…in the majority of patients in all the present clinical groups bears close scrutiny as host specific factors might determine whether or not this organism contributes to brain disease. Two HIV/AIDS patients exhibited sequences similar to Alcaligenaceae; members of this family have been identified as components of the normal flora in Peyer’s patches [33], but members have also been implicated in endocarditis [34], bacteremia [35], [36] and meningitis with or without ventriculitis in neonates [37], [38], HIV-infected persons [39], other immunocompromised adults [40] or following invasive surgery [41]. Thus, identifying members of this family may represent translocation of commensal gut organisms to the brain or a previously unidentified subclinical infection in these patients.…”

Section: Discussionmentioning

confidence: 99%

Brain Microbial Populations in HIV/AIDS: α-Proteobacteria Predominate Independent of Host Immune Status

et al. 2013

View full text Add to dashboard Cite

The brain is assumed to be a sterile organ in the absence of disease although the impact of immune disruption is uncertain in terms of brain microbial diversity or quantity. To investigate microbial diversity and quantity in the brain, the profile of infectious agents was examined in pathologically normal and abnormal brains from persons with HIV/AIDS [HIV] (n = 12), other disease controls [ODC] (n = 14) and in cerebral surgical resections for epilepsy [SURG] (n = 6). Deep sequencing of cerebral white matter-derived RNA from the HIV (n = 4) and ODC (n = 4) patients and SURG (n = 2) groups revealed bacterially-encoded 16 s RNA sequences in all brain specimens with α-proteobacteria representing over 70% of bacterial sequences while the other 30% of bacterial classes varied widely. Bacterial rRNA was detected in white matter glial cells by in situ hybridization and peptidoglycan immunoreactivity was also localized principally in glia in human brains. Analyses of amplified bacterial 16 s rRNA sequences disclosed that Proteobacteria was the principal bacterial phylum in all human brain samples with similar bacterial rRNA quantities in HIV and ODC groups despite increased host neuroimmune responses in the HIV group. Exogenous viruses including bacteriophage and human herpes viruses-4, -5 and -6 were detected variably in autopsied brains from both clinical groups. Brains from SIV- and SHIV-infected macaques displayed a profile of bacterial phyla also dominated by Proteobacteria but bacterial sequences were not detected in experimentally FIV-infected cat or RAG1−/− mouse brains. Intracerebral implantation of human brain homogenates into RAG1−/− mice revealed a preponderance of α-proteobacteria 16 s RNA sequences in the brains of recipient mice at 7 weeks post-implantation, which was abrogated by prior heat-treatment of the brain homogenate. Thus, α-proteobacteria represented the major bacterial component of the primate brain’s microbiome regardless of underlying immune status, which could be transferred into naïve hosts leading to microbial persistence in the brain.

show abstract