A Case of Epididymo-orchitis and Paravertebral Abscess due to Brucellosis

Cesur, Salih; Çiftçi, Ayşe Yilmaz; Sözen, Tuncay Hasip; Tekeli, Emin

doi:10.1053/jinf.2002.1121

Cited by 14 publications

(7 citation statements)

References 11 publications

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“…13 Therefore, a detailed anamnesis together with a correct risk assessment is of the utmost importance to underpin the diagnosis and specific treatment of epididymoorchitis, and it will help to avoid complications such as testicular abscesses or atrophy leading to infertility. [31][32][33] In patients with epididymo-orchitis, the differential diagnosis should include brucellosis when living in an endemic region such as Ecuador, especially when these patients belong to a high-risk population. In this respect, it is interesting to note that, in 2008, epididymo-orchitis was reported in 983,286 hospitalized patients in Ecuador, but only 369 (0.037%) cases were ascribed to brucellosis (diagnostic codes N.45.0-N.45.9 according to International Statistical Classification of Diseases and Related Health Problems).…”

Section: Discussionmentioning

confidence: 99%

First Report of Orchitis in Man Caused by Brucella abortus Biovar 1 in Ecuador

Ron-Román¹,

Saegerman²,

Minda-Aluisa³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. We present a 44-year-old man from a rural community in northern Ecuador who worked on a cattle farm where he was involved with primary veterinary care, including assistance during births (or calving) and placenta retention and artificial insemination, with minimal precautions. In September of 2009, quite abruptly, he developed asthenia and hypersomnia without any apparent cause or symptoms like fever, chills, or night sweats. On November 14, 2009, he suffered from pain and edema in the right testicle that coincided with pain in the abdomen. Clinical, serological, and bacteriological investigations confirmed the first case of unilateral orchitis in man in Ecuador caused by Brucella abortus biovar 1. Because brucellosis is a neglected disease, special attention should be given to it in the training of medical and veterinary students.

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Section: Discussionmentioning

confidence: 99%

First Report of Orchitis in Man Caused by Brucella abortus Biovar 1 in Ecuador

Ron-Román¹,

Saegerman²,

Minda-Aluisa³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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“…14 Genital infection is also frequently seen and usually presents as epididymoorchitis or occasionally as prostatitis, and most cases have multiorgan involvement. 15,16 Development of necrotizing orchitis may require surgical treatment. 15 Brucellosis can affect virtually any tissue or organ, and various literature reports describe Brucella infection of the respiratory system, 17 the skin, 18 and the gastrointestinal tract, 19,20 and involving children.…”

Section: Discussionmentioning

confidence: 99%

Acute brucellosis: presentation, diagnosis, and treatment of 144 cases

Andriopoulos¹,

Tsironi

Deftereos

et al. 2007

International Journal of Infectious Diseases

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“…Brucellosis may present clinically as acute, as chronic following an acute attack or as chronic and of insidious onset. Human brucellosis is a multisystem disease that may present with a broad spectrum of clinical manifestations and its complications can affect almost all organs and systems with varying incidence (Andres Morist et al, 2003;Cesur et al, 2003;Gur et al, 2003). Its clinical manifestations and focal complications are often troublesome in making a clinical diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Protean clinical manifestations and diagnostic challenges of human brucellosis in adults: 16 years' experience in an endemic area

Mantur¹,

Biradar²,

Bidri³

et al. 2006

Journal of Medical Microbiology

149

111

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A prospective study was carried out to elucidate the clinical, epidemiological and laboratory features of human brucellosis. A total of 26 948 blood samples (from adults aged 15 years and above) were screened for serological evidence of brucellosis over a period of 16 years. The slide agglutination/Rose Bengal plate agglutination test gave positive results in 517 patients, of which 509 had detectable titres by the standard tube agglutination test (SAT). The diagnosis of brucellosis was documented in 495 (1?8 %) patients based on diagnostic titres (¢1 : 160, 490 cases) and rising titres from insignificant titres (four cases) by serology and for one case by blood-culture isolation alone. Blood cultures were carried out in 345 cases, of which 191 cases (55?3 %) yielded Brucella melitensis. In 77/79 cases undertaken for follow up, there was a steady fall in 2-mercaptoethanol (2ME) agglutination titres along with clinical improvement (P <0?01). SAT titres remained detectable in most cases for a longer period in spite of an effective antimicrobial therapy and clinical recovery. A substantial number of patients (84?2 %) presented with fever, this being the only complaint in 51?1 % of the cases. Complications were present in 8?8 % of the patients (arthritis excluded): this included the unusual complications of hydrocele (two cases), Stevens-Johnson syndrome (one case) and urinary tract infection (one case). Brucella agglutinins were demonstrated in synovial, testicular, hydrocele and cerebrospinal fluids. There was no clinical suspicion of brucellosis in 439 cases (88?7 %) and the diagnosis was made only by routine serology. A two-drug regimen for 42-84 days with a follow-up 2ME test resulted in lower levels of relapse. These results suggest that, in endemic areas of the world, it should be mandatory to screen routinely for brucellosis due to protean clinical manifestations. INTRODUCTIONBrucellosis is a worldwide zoonotic disease caused by Brucella spp. The genus Brucella comprises Gram-negative, facultative, intracellular pathogens (Alton et al., 1975). Currently, there are six recognized species of Brucella based on phenotypic characteristics, antigenic variation and prevalence of infection in different animal hosts: Brucella abortus (cattle), Brucella canis (dogs), Brucella melitensis (goats, sheep), Brucella neotomae (desert wood rats), Brucella ovis (sheep) and Brucella suis (pigs, reindeer and hares) (Corbel, 1997;Moreno et al., 2002). Recently, two Brucella strains from marine mammals have been reported (Bricker et al., 2000;Cloeckaert et al., 2000) and the names Brucella pinnipediae (seal/otter) and Brucella cetaceae (porpoise/ whale) have been proposed (Cloeckaert et al., 2003). There has also been a report of human infection with marine brucellae (Sohn et al., 2003). Although each species of Brucella has a preferred host, all can infect a wide range of animals, including humans. Brucellosis is a worldwide reemerging zoonosis causing high economic losses and severe human disease. It has areas of high endemicity...

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A Case of Epididymo-orchitis and Paravertebral Abscess due to Brucellosis

Cited by 14 publications

References 11 publications

First Report of Orchitis in Man Caused by Brucella abortus Biovar 1 in Ecuador

First Report of Orchitis in Man Caused by Brucella abortus Biovar 1 in Ecuador

Acute brucellosis: presentation, diagnosis, and treatment of 144 cases

Protean clinical manifestations and diagnostic challenges of human brucellosis in adults: 16 years' experience in an endemic area

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