A case of epithelial-myoepithelial carcinoma of parotid gland.

Basement Membrane–like Substance in Cytologic Diagnosis in Clear Cell Adenocarcinoma of the Minor Salivary Gland of the Palate

“…3 Likewise, CCA and EMC have similar findings histopathologically and cytopathologically. The cytologic findings of EMC reported in the literature consist of 2 cell types, 13 strongly cohesive small cells with scanty cytoplasm and unclear nucleoli and loosely cohesive large cells with abundant cytoplasm and prominent nucleoli. Histopathologically, it also has 2 cell types, columnar cells that form glands and spindleshaped myoepithelial cells located in the outer layer of the glands.…”

“…Histopathologically, it also has 2 cell types, columnar cells that form glands and spindleshaped myoepithelial cells located in the outer layer of the glands. 13 These cell types differentiate EMC from CCA. Furthermore, it is reported that in EMC the inner columnar cells were immunohistochemically positive for AE1 and the outer myoepithelial cells were positive for α-smooth muscle actin (SMA), 13 whereas in the present study, CCA was positive for AE1, an epithelial marker, and negative for α-SMA.…”

“…13 These cell types differentiate EMC from CCA. Furthermore, it is reported that in EMC the inner columnar cells were immunohistochemically positive for AE1 and the outer myoepithelial cells were positive for α-smooth muscle actin (SMA), 13 whereas in the present study, CCA was positive for AE1, an epithelial marker, and negative for α-SMA. Immunohistochemical analysis may confirm the differential diagnosis of the tumors.…”