A case of erythema elevatum diutinum associated with peripheral ulcerative keratitis

Jiao, Ting; Wang, Mingyue

doi:10.1111/j.1440-0960.2011.00816.x

Cited by 10 publications

(4 citation statements)

References 7 publications

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“…Comorbid malignancy occurred in 13 cases (9.77%); three case reports documented an association with lymphoma, two cases with IgA multiple myeloma, two cases with nonspecified multiple myeloma, and there were single cases associated with lung cancer, breast cancer, myelofibroblastic tumor, IgA‐MGUS, and myelodysplastic syndrome. Ocular involvement was reported in 10 cases (7.5%); the most common comorbid ophthalmologic finding was peripheral ulcerative keratitis, an association reported in six cases …”

Section: Resultsmentioning

confidence: 99%

Erythema elevatum diutinum: a case report and review of literature

Doktor¹,

Hadi

Phelps

et al. 2018

Int J Dermatology

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Erythema elevatum diutinum (EED) is a rare cutaneous leukocytoclastic vasculitis thought to be related to increased levels of circulating antibodies. It has been shown to be associated with HIV infection, tuberculosis, as well as various autoimmune diseases. A retrospective review of all cases of EED indexed in PubMed between 1990 and 2014 was performed. Inclusion criteria for articles was availability of full text in English and a biopsy-confirmed diagnosis of EED. All other articles were excluded. Cases were stratified by age and anatomic location of the lesions. Treatment response was coded as "complete," "partial," and "none." A total of 133 cases of EED with 381 lesions detailed in case reports and case series were included. Twenty-one cases were associated with HIV. Of 47 patients with reported paraproteinemias, IgA paraproteinemia was found in 57.45%, IgG paraproteinemia in 29.8%, IgM paraproteinemia in 10.6%, and IgD paraproteinemia in 2.1% of cases. Of 40 (30.1%) patients with reported comorbid autoimmune disease, rheumatoid arthritis was associated with 10 cases. Cancer was found to be associated with 9.77% of cases. Seventy-five patients were treated with dapsone, with 36 (48%) achieving complete treatment response, 24 (32%) achieving partial response, and seven (9.3%) achieving no response. Keeping the clinical associations of EED in mind, especially malignancy, is critical in management of the disease. More structured studies need to take place in order to fully define the mechanisms and strength of these associations.

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Section: Resultsmentioning

confidence: 99%

Erythema elevatum diutinum: a case report and review of literature

Doktor¹,

Hadi

Phelps

et al. 2018

Int J Dermatology

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“…One study assessed the use of dapsone gel alongside oral dapsone. Topical dapsone provided localized clearing (with a low risk of side‐effects) and further resolution was seen following the addition of oral dapsone . An effective clinical response was seen in seven (11%) patients who were treated with dapsone alongside an additional agent, e.g.…”

Section: Treatment Of Eedmentioning

confidence: 99%

“…Topical dapsone provided localized clearing (with a low risk of side-effects) and further resolution was seen following the addition of oral dapsone. 56 An effective clinical response was seen in seven (11%) patients who were treated with dapsone alongside an additional agent, e.g. steroids (n = 1), antibiotics (n = 1), colchicine (n = 1), excision (n = 1), antiretroviral (n = 1) and gluten-free diet (n = 2).…”

Section: Dapsonementioning

confidence: 99%

Erythema elevatum diutinum: a review of presentation and treatment

Momen

Jorizzo

Al‐Niaimi

2014

Acad Dermatol Venereol

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Erythema elevatum diutinum (EED) is a rare, chronic and treatable skin condition. It has many histological mimics and is often associated with a variety of underlying systemic diseases, when these are present the management and prognosis dictates the course of the EED. This review aims to highlight the differential diagnosis, clinical manifestations of EED and the possible underlying systemic disease. It is important for clinicians to be aware that EED may predate underlying conditions and the presence of lesions may indicate underlying disease activity. In some cases one may need 'search' for underlying disease. Treatment of these lesions is notoriously difficult. Dapsone is used as the mainstay of treatment, however other options exist. We have highlighted different treatment options and suggested a treatment algorithm. In some cases, treatment may need to be targeted at underlying disease.

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“…Lesions are usually asymptomatic but typically persist for years, becoming increasingly firm and nodular. Rarely, peripheral ulcerative keratitis can be associated with EED; most eye symptoms usually improve along with the skin lesions after treatment . EED tends to be chronic and progressive in nature.…”

mentioning

confidence: 99%