A Case of Erythromelalgia: Good Response to Combination Treatment with Pregabalin and Selective Serotonin Reuptake Inhibitor

Abstract

Observation: Erythromelalgia is a rare entity characterized by episodic acral burning pain, heat and redness in the extremities. Symptoms are triggered by a warm environment and can be relieved by cooling. The pain may be severe enough to disrupt a person's quality of life. The cases in which there is no underlying disease are known as primary, whereas the cases associated with different diseases are known as secondary erythromelalgia. Here, a case of erythromelalgia, secondary to type 2 diabetes mellitus, is presented, with a good response to treatment with a combination of selective serotonin reuptake inhibitors and pregabalin.