A Case of Feline Gastrointestinal Eosinophilic Sclerosing Fibroplasia Associated with Phycomycetes

Grau‐Roma, Llorenç; Galindo-Cardiel, I.; Isidoro-Ayza, Marcos; Fernández, María Teresa; Majó, Natàlia

doi:10.1016/j.jcpa.2014.08.005

Cited by 24 publications

(43 citation statements)

References 10 publications

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“…Several aetiological factors, such as bacterial infection, penetrating wounds from a migrating foreign body, herpesvirus infection, fungal infection, food hypersensitivity and genetic eosinophil dysregulation have been proposed as possible triggers for the eosinophilic infl ammatory response (Craig et al 2009;Weissman et al 2013;Grau-Roma et al 2014). However, immunohistochemistry was negative for coronavirus and herpesvirus -type 1 in 12 FGESF cases (Linton et al 2015).…”

Section: Discussionmentioning

confidence: 99%

“…It is presumed that eosinophils cause the specific fibrosis of FGESF and play a key role in the pathogenesis of FGESF (Craig et al 2009;Suzuki et al 2013;Weissman et al 2013). Previously, bacterial or fungal infection has been considered to be involved in the pathogenesis of FGESF (Ozaki et al 2003;Grau-Roma et al 2014), but in subsequent cases, no pathogens were detected (Craig et al 2009;Suzuki et al 2013;Weissman et al 2013). In the most recent study bacteria were found in nine of 13 FGESF cases (Linton et al 2015).…”

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confidence: 99%

“…In the most recent study bacteria were found in nine of 13 FGESF cases (Linton et al 2015). Several mechanisms, such as penetrating wounds from a migrating foreign body, genetic eosinophil dysregulation, herpesvirus infection, fungal infection and food hypersensitivity, have also been proposed to be involved in the pathogenesis of FGESF (Craig et al 2009;Weissman et al 2013;Grau-Roma et al 2014).…”

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confidence: 99%

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Recurrent feline gastrointestinal eosinophilic sclerosing fibroplasia and presumptive eosinophilic cystitis in a domestic short-haired cat: a case report

Brložnik¹,

Faraguna²,

Goc³

et al. 2017

Vet. Med. - Czech

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This report describes recurrent feline gastrointestinal eosinophilic sclerosing fibroplasia (FGESF) and eosinophilic cystitis in an 8-year-old domestic short-haired cat. The cat presented with incontinence, pollakiuria, vomiting and weight loss. An abdominal mass was palpated and ultrasonography revealed severe segmental thickening of the jejunal wall with loss of layering. Complete resection of the jejunal mass was performed. The resected mass was composed of branching trabeculae of dense collagen, intermixed with bundles of large fibroblasts and inflammatory cells, which is consistent with FGESF. One year later, a new mass reoccurred in another intestinal segment. Between both FGESF occurrences, mycoplasmas were cultured from urine and fine needle aspiration of the urinary bladder wall showed numerous eosinophils only; therefore, a presumptive diagnosis of eosinophilic cystitis was made. All haematological analyses performed within the one-year period revealed eosinophilia.

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confidence: 99%

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confidence: 99%

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Recurrent feline gastrointestinal eosinophilic sclerosing fibroplasia and presumptive eosinophilic cystitis in a domestic short-haired cat: a case report

Brložnik¹,

Faraguna²,

Goc³

et al. 2017

Vet. Med. - Czech

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confidence: 99%

“…This disease has been reported in cats and pumas ( Puma concolor ) [2,3,4, 9]. The etiology of this disease is the infection (bacteria, fungi and nematodes), foreign body or unknown [2,3,4, 7, 9]. Macroscopically, the lesion is observed as an ulcerated intramural mass at the pyloric sphincter and the ileocecocolic junction [2,3,4, 9].…”

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Jejunal fibroplasia in a rat

Kawasako¹,

Kanno²,

Hamamura³

2017

The Journal of Veterinary Medical Science

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A jejunal nodular mass was identified in an aging rat. Histologically, the boundaries between the lesion and surrounding normal tissue as well as between the inner circular muscle and outer longitudinal muscle were indistinct. The lesion consisted of abundant eosinophilic matrix and cells with a large round to oval nucleus and indistinct cytoplasm. There was no characteristic proliferating pattern, nuclear polymorphism and a low mitotic figure count. Masson’s trichrome stain revealed that the intestinal smooth muscles were replaced by the abundant collagen fiber. Immunohistochemistry revealed that the cells with a large round to oval nucleus were labeled with anti-vimentin antibody and not with anti-α smooth muscle actin antibody, suggesting that these cells were fibroblasts. The mass was diagnosed as jejunal fibroplasia.

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Feline gastrointestinal eosinophilic sclerosing fibroplasia associated with Candida albicans

Almendros,

Giuliano,

Tse

et al. 2024

Veterinary Medicine & Sci

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Feline gastrointestinal eosinophilic sclerosing fibroplasia (FGESF) is a rare and poorly understood disease characterised by the infiltration of eosinophils and the development of fibrous tissue within the gastrointestinal tract of cats. A 2‐year‐old female neutered Ragdoll was presented for signs consistent with extrahepatic biliary tract obstruction (EHBO), including jaundice, hyporexia and lethargy. Marked progressive hyperbilirubinemia and mild anaemia were also present. Abdominal ultrasonography suggested a duodenal mass and pancreatitis as the cause of EHBO. Cytopathological results from fine needle aspirates detected mast cells and eosinophils in the duodenal mass and eosinophils in the spleen and the liver, suggestive of a possible mast cell tumour. A cholecystojejunostomy and a duodenotomy were performed to divert the biliary outflow and obtain biopsy samples, respectively. Eosinophilic sclerosing fibroplasia in the duodenal mass and fungal elements in an abdominal lymph node were reported on histopathological examination. A pan‐fungal PCR targeting ITS2 performed on DNA extracted from an abdominal lymph node detected Candida albicans. This report adds to the growing body of evidence that FGESF can occur in association with fungal infections.

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A Case of Feline Gastrointestinal Eosinophilic Sclerosing Fibroplasia Associated with Phycomycetes

Cited by 24 publications

References 10 publications

Recurrent feline gastrointestinal eosinophilic sclerosing fibroplasia and presumptive eosinophilic cystitis in a domestic short-haired cat: a case report

Recurrent feline gastrointestinal eosinophilic sclerosing fibroplasia and presumptive eosinophilic cystitis in a domestic short-haired cat: a case report

Jejunal fibroplasia in a rat

Feline gastrointestinal eosinophilic sclerosing fibroplasia associated with Candida albicans

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