moderation and not hope, like Mahomet, to cleave the moon in twain.Advanced arteriosclerosis is too generally neglected, and intoxications of one kind or another are for the most part responsible for it. Our prophylactic and curative measures are readily understood. It is weil known that the relatively great fatality of pneumonia and other acute diseases is explained by the greater toxemia which exists late in life. Besides this, the autointoxication increases the blood pressure and induces prematurely the fatal events of cerebral, cardiac and renal diseases. Almost as deplorable as these are the conditions of unnatural excitement, confusion and depression from which many people unnecessarily suffer in early old age. Still further there may be found in vascular disease the source of much severe pain from which old people suffer. This pain is often referable to the aorta, at times to those forms of aortitis which Clifford Allbutt has described, and also to aortitis and