A case of follicular mucinosis treated successfully with minocycline

Alopecia Mucinosa: Report of a Case and Review

“…49 Yotsumoto et al 49 reported a case of a 36-year-old male with idiopathic follicular mucinosis that responded within two weeks to minocycline with no recurrence. We chose not to continue the patient on oral steroids because of the long-term potential consequences.…”

“…49 In vitro studies have shown that minocycline has the ability to inhibit epidermal keratinocyte production of TNF-A and increase the production of IL-1A. 49, 60 Yotsumoto et al 49 proposed the theory that minocycline decreases TNF-A production by inhibiting tissue matrix metalloproteinases, which are required for posttranslational processing of TNF-A. 49 There is evidence that cell-mediated immunity plays a role in the pathogenesis of alopecia mucinosa.…”

“…49 Minocycline is not only an antimicrobial agent; it has been shown to inhibit matrix metalloproteinases (e.g., collagenase), 59 phospholipase A2, 59 polymorphonuclear cell chemotaxis, and nitric oxide production. 49 In vitro studies have shown that minocycline has the ability to inhibit epidermal keratinocyte production of TNF-A and increase the production of IL-1A.…”

“…49 Minocycline is not only an antimicrobial agent; it has been shown to inhibit matrix metalloproteinases (e.g., collagenase), 59 phospholipase A2, 59 polymorphonuclear cell chemotaxis, and nitric oxide production. 49 In vitro studies have shown that minocycline has the ability to inhibit epidermal keratinocyte production of TNF-A and increase the production of IL-1A. 49, 60 Yotsumoto et al 49 proposed the theory that minocycline decreases TNF-A production by inhibiting tissue matrix metalloproteinases, which are required for posttranslational processing of TNF-A.…”

Successful Treatment of Recalcitrant Primary Follicular Mucinosis with Indomethacin and Low-dose Intralesional Interferon Alpha

“…Corticosteroids, dapsone, minocycline, superficial X-ray, indomethacin, and interferons have been used with various results in individual cases 1,[3][4][5][6][7] . However, effective therapeutic options for FM have remained elusive.…”