A case of fulminant type 1 diabetes mellitus after influenza B infection

Sano, Hiroyuki; Terasaki, Jungo; Tsutsumi, Chiharu; Imagawa, Akihisa; Hanafusa, Toshiaki

doi:10.1016/j.diabres.2007.10.030

Cited by 50 publications

(35 citation statements)

References 4 publications

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“…In fact, there have been many case reports in which the occurrence of FTD has been associated with evidence of several viral infections such as coxsackie virus, echovirus, human herpes virus 6, herpes simplex virus, mumps virus, and influenza (12,13). In our case, however, the patient did not show any suspicious symptoms of antecedent viral infection.…”

Section: Discussioncontrasting

confidence: 39%

The First Vietnamese Patient with Fulminant Type 1 Diabetes Mellitus

Kim

Hahm

et al. 2012

Intern. Med.

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A 23-year-old pregnant woman had a stillbirth at 30 weeks gestation due to abrupt diabetic ketoacidosis. The patient had a normal HbA1c, severe hyperglycemia, negative islet cell autoantibodies, and very low insulin secretion capacity. The viral markers associated with fulminant type 1 diabetes were negative. The patient's human leukocyte antigen genotypes were DRB1*04:06 and DQB1*03:01/05:02, not common subtypes for fulminant type 1 diabetes. This is the first Vietnamese patient with fulminant type 1 diabetes mellitus.

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Section: Discussioncontrasting

confidence: 39%

The First Vietnamese Patient with Fulminant Type 1 Diabetes Mellitus

Kim

Hahm

et al. 2012

Intern. Med.

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“…Our patient presented with fever and fatigue without any other symptoms before developing FT1D, and the Coxsackie A2 virus infection was confirmed serologically. Table 2 summarizes the reported cases in which virus infection was proven to be involved in the development of FT 1D (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). These cases include adults of both sexes.…”

Section: Discussionmentioning

confidence: 99%

Fulminant Type 1 Diabetes Mellitus Associated with Coxsackie Virus Type A2 Infection: A Case Report and Literature Review

et al. 2016

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A 65-year-old Japanese man presented to our hospital in June 2013 with a 6-day history of fever and fatigue, a 24-h history of thirst, and polyuria. His temperature was 37.8 and he was alert. However, laboratory tests revealed severe hyperglycemia, undetectable C-peptide levels, and diabetic ketoacidosis. Serum antibody testing confirmed a Coxsackie virus A2 infection. A variety of viral infections are reported to be involved in the development of fulminant type 1 diabetes mellitus (FT1D). Our patient is the first reported case of FT1D associated with Coxsackie virus A2 infection and supports the etiological role of common viral infections in FT1D.

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“…Possible viral involvement in the etiology of T1D has been suggested by several authors. Viruses associated with human T1D include enteroviruses, such as coxsackievirus B (CVB) (46)(47)(48), but also measles virus, congenital rubella virus, mumps virus, cytomegalovirus (49)(50)(51), and influenza B virus (52). Rotavirus and reovirus have additionally been shown to be diabetogenic in mice (49,53).…”

Section: Discussionmentioning

confidence: 99%

Influenza A Viruses Grow in Human Pancreatic Cells and Cause Pancreatitis and Diabetes in an Animal Model

Capua

Mercalli²,

Pizzuto

et al. 2013

J Virol

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g Influenza A viruses commonly cause pancreatitis in naturally and experimentally infected animals. In this study, we report the results of in vivo investigations carried out to establish whether influenza virus infection could cause metabolic disorders linked to pancreatic infection. In addition, in vitro tests in human pancreatic islets and in human pancreatic cell lines were performed to evaluate viral growth and cell damage. Infection of an avian model with two low-pathogenicity avian influenza isolates caused pancreatic damage resulting in hyperlipasemia in over 50% of subjects, which evolved into hyperglycemia and subsequently diabetes. Histopathology of the pancreas showed signs of an acute infection resulting in severe fibrosis and disruption of the structure of the organ. Influenza virus nucleoprotein was detected by immunohistochemistry (IHC) in the acinar tissue. Human seasonal H1N1 and H3N2 viruses and avian H7N1 and H7N3 influenza virus isolates were able to infect a selection of human pancreatic cell lines. Human viruses were also shown to be able to infect human pancreatic islets. In situ hybridization assays indicated that viral nucleoprotein could be detected in beta cells. The cytokine activation profile indicated a significant increase of MIG/CXCL9, IP-10/CXCL10, RANTES/CCL5, MIP1b/CCL4, Groa/CXCL1, interleukin 8 (IL-8)/CXCL8, tumor necrosis factor alpha (TNF-␣), and IL-6. Our findings indicate that influenza virus infection may play a role as a causative agent of pancreatitis and diabetes in humans and other mammals.

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A case of fulminant type 1 diabetes mellitus after influenza B infection

Cited by 50 publications

References 4 publications

The First Vietnamese Patient with Fulminant Type 1 Diabetes Mellitus

The First Vietnamese Patient with Fulminant Type 1 Diabetes Mellitus

Fulminant Type 1 Diabetes Mellitus Associated with Coxsackie Virus Type A2 Infection: A Case Report and Literature Review

Influenza A Viruses Grow in Human Pancreatic Cells and Cause Pancreatitis and Diabetes in an Animal Model

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