A Case of G-CSF–Producing Histiocytic Sarcoma of the Stomach

Hanaoka, Toshiharu; Jingu, Kazuhiko; Tochigi, Toru; Hoshino, Isamu; Uematu, Takeshi; Matsubara, Hisahiro

doi:10.9738/intsurg-d-14-00023.1

Cited by 10 publications

(5 citation statements)

References 11 publications

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“…In general, the following criteria are used as the diagnostic standard for detecting a G-CSF-producing tumor: (1) an increased number of leukocytes, primarily mature neutrophils, with no other explanatory factors; (2) elevated serum G-CSF; (3) a reduction in the leukocyte count following tumor resection; and (4) confirmation of G-CSF production via immunostaining (10). However, clinically, positive immunostaining is not a definitive finding for the diagnosis of G-CSF-producing tumors (11).…”

Section: Discussionmentioning

confidence: 99%

Rapid progression of a granulocyte colony-stimulating factor-producing liver tumor metastasized from esophagogastric junction cancer: A case report and literature review

et al. 2018

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Abstract. The current study presents the case of a 72-year-old woman with a rapidly enlarged liver metastasis from esophagogastric junction (EGJ) cancer, accompanied by progressive leukocytosis (47,680/µl) and elevated serum granulocyte colony-stimulating factor (G-CSF; 779 pg/ml). The patient underwent right hemihepatectomy 26 months after a total gastrectomy. On the seventh post-operative day the patient's leukocyte count and serum G-CSF level decreased to 4,280/µl and ≤19.5 pg/ml, respectively. Histologically, the lesion was a well to moderately differentiated adenocarcinoma similar to the primary lesion. Therefore, this tumor was clinically diagnosed as a G-CSF-producing liver metastasis from EGJ cancer, although immunohistochemical staining for G-CSF was negative. A right pulmonary nodule detected simultaneously with the hepatic mass was resected four months following the hepatectomy and was diagnosed as a pulmonary metastasis. The patient's leukocyte count was normal at the time of her initial surgery for EGJ cancer, and her clinical course varied for different metastatic sites. The liver metastasis was accompanied by progressive leukocytosis and elevated serum G-CSF and demonstrated rapid tumor growth during a six-month period, whereas the non-G-CSF-producing pulmonary metastasis grew slowly during the same period. In addition 21 reported cases of G-CSF-producing upper gastrointestinal tract cancer were reviewed to elucidate the clinicopathological features of this disease.

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Section: Discussionmentioning

confidence: 99%

Rapid progression of a granulocyte colony-stimulating factor-producing liver tumor metastasized from esophagogastric junction cancer: A case report and literature review

et al. 2018

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“…G-CSF and GM-CSF are cytokines that promote production of neutrophils, monocytes, eosinophils and basophils, (Mehta et al, 2015;Shochat et al, 2007) and may have been related to leucocytosis in both our cases. Asano et al (1997) 4) evidence of G-CSF expression in the tumour tissue (Hanaoka et al, 2015). Definitions (1), ( 3) and (4) were fulfilled in both cases, whereas the increase in the serum G-CSF concentration could not be investigated because anti-canine G-CSF antibodies were not available.…”

Section: Discussionmentioning

confidence: 99%

Neutrophilic leucocytosis induced by granulocyte colony‐stimulating factor and interleukin‐6 in canine primary lung adenocarcinoma

Tamura

Ishigaki

Iizuka

et al. 2021

Veterinary Medicine & Sci

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Background: Neutrophilic leucocytosis as a paraneoplastic syndrome may occur in dogs with lymphoma, renal carcinoma, rectal polyps and metastatic fibrosarcoma.However, the information on canine lung adenocarcinoma with neutrophilic leucocytosis is lacking.Objective: This study aimed to describe the clinical features and cytokine profiles of canine patients with primary lung adenocarcinoma and neutrophilic leucocytosis.Methods: Two dogs (cases #1 and #2), each with a solitary lung adenocarcinoma, were included. Both cases had leucocytosis and underwent lung lobectomy. The resected tumours were analysed for the expression of granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin-6 (IL6) by quantitative real-time PCR compared with normal lung tissues.Results: At the initial examination, neither patient had any clinical signs or fever. White blood cell count (WBC) was 58,300/μl and 32,900/μl in cases #1 and #2, respectively.The gene expression of G-CSF increased 6.7-and 19.7-fold in cases #1 and #2, respectively. The gene expression of IL6 markedly increased (30-fold) in case #1, whereas it increased slightly (1.9-fold) in case #2. On the other hand, that of GM-CSF was slightly changed in both cases. The WBC count postoperatively decreased to within the normal range in both cases. The postoperative survival times were 347 and 118 days in cases #1 and #2, respectively. Conclusions:This study describes G-CSF and IL6 producing lung adenocarcinoma associated with neutrophilic leucocytosis in dogs. Canine patients with pulmonary adenocarcinomas that have elevated G-CSF and IL6 levels may have a guarded prognosis. Further investigations are needed to clarify the prognosis of canine cytokineproducing lung adenocarcinoma.

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“…6 Gastric HS was described to involve multiple sites, including colon 3 , jejunum 5 , esophagus 9 , pancreas and liver. 6,10 The imaging features of gastric HS are nonspecifi c and it is diffi cult to differentiate it from other gastric malignancies by radiological evaluation alone. 8 There is no accepted staging, but HS is typically an FDG-avid neoplasm 6,11 and staging relies on bone marrow biopsy and CT or PET/CT scans to look for multifocal disease.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Primary Histiocytic Sarcoma of the Stomach

et al. 2018

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Histiocytic sarcoma is a rare lymphohematopoietic malignancy with aggressive clinical course and poor therapy response. The diagnosis relies on the confirmation of its histiocytic lineage and exclusion of other poorly differentiated tumors. Most of the cases present in extranodal sites, but primary gastric involvement is exceptional. We report a case of a 69-year-old woman with epigastric pain and systemic symptoms. Gastroscopy findings and biopsy report suggested a malignant neoplasm. The patient underwent distal subtotal gastrectomy with a 6-cm tumor in the body and antrum of the stomach and ten associated enlarged perigastric lymph nodes. Microscopically they were infiltrated with atypical tumor cells and immunohistochemical staining was positive for CD68, lysozyme, CD45, and CD4; 45% of the cells stained for Ki-67. The pathologic diagnosis was histiocytic sarcoma. CT body scans showed only enlarged retroperitoneal and abdominal lymph nodes. The patient received six cycles of CHOEP chemotherapy with complete therapeutic response, but three months later she experienced an aggressive systemic sarcoma recurrence and although salvage chemotherapy was initiated she died of progressive disease. The presented case widens the differential diagnosis of gastric malignancies, and emphasizes the significance of immunohistochemical examination for histiocytic sarcoma diagnosis. The collection and evaluation of cases of gastric histiocytic sarcoma are important to obtain further progress in prognosis and treatment.

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A Case of G-CSF–Producing Histiocytic Sarcoma of the Stomach

Cited by 10 publications

References 11 publications

Rapid progression of a granulocyte colony-stimulating factor-producing liver tumor metastasized from esophagogastric junction cancer: A case report and literature review

Rapid progression of a granulocyte colony-stimulating factor-producing liver tumor metastasized from esophagogastric junction cancer: A case report and literature review

Neutrophilic leucocytosis induced by granulocyte colony‐stimulating factor and interleukin‐6 in canine primary lung adenocarcinoma

A Rare Case of Primary Histiocytic Sarcoma of the Stomach

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