A Case of Gastric Adenocarcinoma in a Shih Tzu Dog: Successful Treatment of Early Gastric Cancer

Abstract

A 9-year-old castrated male Shih Tzu dog was referred to us, because of chronic vomiting. The patient’s hematological, radiographic, ultrasonographic, endoscopic and histological examinations were evaluated for diagnosis. Hematologic analysis indicated moderate anemia and azotemia. Based on the imaging studies, an oval-shaped mass was identified in the gastric pylorus area. A proliferative mass was found on endoscopic examination, and we performed biopsy using grasping forceps. The histopathological findings of the biopsy specimens indicated hypertrophic gastritis, and Y-U pyloroplasty was performed. However, histopathological examination of the surgically resected mass revealed tubular adenocarcinoma of the stomach. Then, carboplatin chemotherapy was performed 4 times for 13 weeks. Clinical signs, such as vomiting, were resolved gradually after surgery and chemotherapy, and the patient’s condition was managed favorably until recently (30 months after surgery). This case report describes clinical features, imaging studies, endoscopic characteristics and histopathological and immunohistochemical features of gastric tubular adenocarcinoma as early gastric cancer in a dog.

Contrast‐enhanced computed tomography may be helpful for characterizing and staging canine gastric tumors

“…Features of extranodal lymphomas are not specific and usually cannot be differentiated from those of other forms of lymphoma . Primary differential diagnoses for gastrointestinal lymphoma in dogs include adenocarcinoma and smooth muscle tumors . In humans and dogs, adenocarcinoma is malignant and epithelial in origin, and infiltrates submucosal areas .…”

“…Tumors of the canine gastrointestinal tract are uncommon and account for less than 1% of all reported neoplasms . The majority of gastric tumors are malignant, epithelial in origin, and affect the distal two‐thirds of the stomach .…”

“…The majority of gastric tumors are malignant, epithelial in origin, and affect the distal two‐thirds of the stomach . Reported tumors include adenocarcinomas, leiomyosarcomas, lymphomas, leiomyomas, polyps, adenomas, gastrointestinal stromal tumor, plasmocytoma, mast cell, and fibrosarcoma . In veterinary medicine, standard imaging modalities used to characterize and stage gastric masses include radiography, ultrasonography, and endoscopy .…”

“…Tumors of the canine gastrointestinal tract are uncommon and account for less than 1% of all reported neoplasms. 1,2 The majority of gastric tumors are malignant, epithelial in origin, and affect the distal two-thirds of the stomach. 3,4 Reported tumors include adenocarcinomas, leiomyosarcomas, lymphomas, leiomyomas, polyps, adenomas, gastrointestinal stromal tumor, plasmocytoma, mast cell, and fibrosarcoma.…”

“…3,4 Reported tumors include adenocarcinomas, leiomyosarcomas, lymphomas, leiomyomas, polyps, adenomas, gastrointestinal stromal tumor, plasmocytoma, mast cell, and fibrosarcoma. 2,[5][6][7][8][9] In veterinary medicine, standard imaging modalities used to characterize and stage gastric masses include radiography, ultrasonography, and endoscopy. 9,10 On radiography, gastric masses may be recognizable if the stomach is filled with air.…”