A case of gastric plasmacytoma associated with Helicobacter pylori infection: Improvement of abnormal endoscopic and EUS findings after H pylori eradication

Kato, Kimitoshi; Sugitani, Masahiko; Nagata, Toshihiko; Nishinarita, Susumu; Kawamura, Fumio; Takahashi, Yasuo; Ishii, Yoshinori; Kawamura, Yo; Komuro, Sachiko; Yanai, Mitsuru; Nemoto, Norimichi; Arakawa, Yasuyuki

doi:10.1016/s0016-5107(01)70416-6

Cited by 13 publications

(12 citation statements)

References 10 publications

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“…To the best of our knowledge, five cases reports exist in literature with successful or near-successful treatment of GPs by H. pylori eradication [8][9][10][11][12]. Therefore, Kato et al [10] and Stasi et al [9] proposed H. pylori eradication as first-line therapy for the disease at an early stage.…”

Section: Discussionmentioning

confidence: 99%

Primary gastric plasmacytoma associated with Helicobacter pylori infection: a report of two cases with different prognosis

Gan

2010

Int J Hematol

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We describe two cases of primary gastric plasmacytoma (GP) associated with Helicobacter pylori infection. Case 1 was that of a 58-year-old man with epigastric pain. H. pylori was eradicated before surgical resection was performed, and after the therapy, the tumor size was reduced. A postoperative pathological examination revealed that the tumor was in early stage and histological grade was grade 1. After 44 months of operation, the patient was in complete remission with no evidence of local relapse or progression to systemic MM. Case 2 was that of a 70-year-old woman with a history of melena. H. pylori eradication was not presented preoperatively. The resected specimen showed the tumor was in advanced stage and histological grade 3. GP eventually progressed to MM and she died of pulmonary infection. In our opinion, GP cannot be eradicated with H. pylori eradication, but disease progression can be effectively controlled to a certain extent. The prognosis of this disease is relatively fair when treated at an early stage. In addition to the treatment, the difference in prognosis could be associated with age, the stage of the tumor, and histological grade.

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Section: Discussionmentioning

confidence: 99%

Primary gastric plasmacytoma associated with Helicobacter pylori infection: a report of two cases with different prognosis

Gan

2010

Int J Hematol

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“…It is still controversial whether or not H. pylori eradication is truly beneficial in the treatment of gastric plasmacytoma. 6,[9][10][11][12][13] In contrast to other cases, eradication therapy for H. pylori was not performed here.…”

Section: Discussionmentioning

confidence: 96%

Complete Endoscopic Resection of Very Early Stage Gastric Plasmacytoma

Kim¹,

Kim²,

Lee³

et al. 2010

Gut Liver

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Gastric plasmacytomas are very rare, and most are not detected until the disease has progressed to an advanced stage. However, there have been recent reports of cases of early-stage gastric plasmacytoma, in which neoplastic cells are confined to the mucosa or submucosa. Here we report a case of a very early stage gastric plasmacytoma that was confined to the lamina propria of the gastric mucosa. The lesion was successfully and completely removed by endoscopic submucosal dissection, and the surveillance endoscopy showed no recurrence during the follow-up of 40 months. This report appears to be the first documented case of complete endoscopic removal of a primary gastric plasmacytoma. (Gut Liver 2010;4: 547-550)

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“…Perhaps, the most important evidence of the association of H. pylori infection with plasma cell dyscrasias is that some plasmacytomas disappear after the eradication of H. pylori. The authors who have analyzed this facet of infection by H. pylori have agreed to recommending that in all patients with these manifestations be offered the opportunity of evaluated and eradicate the infection if present [243][244][245]. Other associations described include a clear interaction between MALT lymphoma of the stomach and MGUS [246] as well as Waldenström's disease and MALT [247].…”

Section: Plasma Cell Dyscrasiasmentioning

confidence: 99%

Helicobacter pylori and Hematologic Diseases

Campuzano-Maya¹

2016

Extradigestive Manifestations of Helicobacter Pylori Infection - An Overview

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Helicobacter pylori infection is the most common infection of the human species, with developing countries displaying a marked disadvantage in contrast to developing countries. While H. pylori infection is asymptomatic in most infected individuals, it is intimately related to malignant diseases of the stomach, such as gastric cancer and gastric MALT lymphoma, as well as benign diseases, for example chronic gastritis and duodenal and gastric peptic ulcers. Since the discovery that gastric mucosa could be colonized by bacteria, evidence of greater than 50 extragastric manifestations has been reported, linking H. pylori infection and the development of diseases associated with cardiology, dermatology, endocrinology, obstetrics and gynecology, hematology, pneumology, neurology, odontology, ophthalmology, otorhinolaryngology, and pediatrics. This chapter presents the extragastric manifestations of H. pylori infection expressed through hematologic diseases; particularly those included in the international consensus, and discusses guidelines for the management of H. pylori infection, such as iron deficiency, vitamin B 12 (cobalamin) deficiency, and immune thrombocytopenia. Other manifestations reviewed include immune neutropenia, antiphospholipid syndrome, and plasma cell dyscrasias, such us monoclonal gammopathy of undetermined significance, multiple myeloma, and Henoch-Schönlein purpura.

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A case of gastric plasmacytoma associated with Helicobacter pylori infection: Improvement of abnormal endoscopic and EUS findings after H pylori eradication

Cited by 13 publications

References 10 publications

Primary gastric plasmacytoma associated with Helicobacter pylori infection: a report of two cases with different prognosis

Primary gastric plasmacytoma associated with Helicobacter pylori infection: a report of two cases with different prognosis

Complete Endoscopic Resection of Very Early Stage Gastric Plasmacytoma

Helicobacter pylori and Hematologic Diseases

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