A case of generalized morphea profunda following SARS-CoV-2 infection

Stephens, Michael; Moore, Duncan F; Dau, Jonathan; Jobbagy, Soma; Neel, Victor A.; Bolster, Marcy B.; Fedeles, Flavia

doi:10.1016/j.jdcr.2022.02.033

Cited by 3 publications

(6 citation statements)

References 9 publications

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“…Morphea has been described in autoimmune diseases such as systemic lupus erythematosus, vitiligo, alopecia areata, rheumatoid arthritis, and autoimmune thyroiditis. It may be linked to various environmental factors, including trauma, radiation, medications, infections, and vaccines [8]. Borrelia burgdorferi is the infectious pathogen most associated with morphea [8].…”

Section: Discussionmentioning

confidence: 99%

“…It may be linked to various environmental factors, including trauma, radiation, medications, infections, and vaccines [8]. Borrelia burgdorferi is the infectious pathogen most associated with morphea [8]. Other infections with a probable association include hepatitis B virus, hepatitis C virus, Cytomegalovirus, toxoplasmosis, Helicobacter pylori, and human endogenous retroviruses [8].…”

Section: Discussionmentioning

confidence: 99%

“…Skin and soft tissue modifications observed in case of morphea and infection by different viruses (as well as related vaccines) can trigger vascular lesions through neo-intimal proliferation by the overproduction of profibrotic cytokines (such as TGF-beta, PDGF-alpha, and PDGF-beta). Thus, SARS-CoV-2 infection induces cutaneous vascular lesions with massive cytokine release, activation of adhesion molecules, and T cells, potentially contributing to connective tissue disorders [2,[5][6][7][8][9].…”

Section: Discussionmentioning

confidence: 99%

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Linear Morphea in the Context of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Unique Dermatological Manifestation

Harb,

Rached,

El Sayed

2024

Cureus

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Morphea, a rare skin disorder characterized by localized areas of thickened and sclerotic skin, typically presents as circumscribed plaques. The linear variant, however, manifests as linear bands of sclerosis affecting the extremities, and its association with coronavirus disease 2019 (COVID-19) has not been documented until now. In this article, we present the case of a 22-year-old previously healthy female patient who contracted COVID-19 complicated by an erythroedema on the back of the right hand, extending notably to the forearm on the 10th day of the infection. Skin biopsy revealed dermal and septal hypodermal fibrosis with a mild lymphocytic interstitial infiltrate in the dermis consistent with morphea. Treatment with lowdose corticosteroids was started, and regular follow-up was established. An isolated recurrence of cutaneous symptoms was observed after the first COVID-19 vaccination (Sputnik V) administered five months after the initial infection, with spontaneous regression in 10 days. This clinical evolution underscores the importance of a comprehensive understanding of dermatological manifestations in COVID-19, particularly in the context of post-infection vaccination.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Linear Morphea in the Context of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Unique Dermatological Manifestation

Harb,

Rached,

El Sayed

2024

Cureus

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“…In the available literature, the majority of references focus on the occurrence of morphea following vaccination against COVID-19 [8,9]. Only a limited number of isolated studies or reports have highlighted the induction of morphea as a result of COVID-19 infection itself [10][11][12].…”

Section: Discussion Morphea After Vaccine Against Covid-19 Vaccine An...mentioning

confidence: 99%

Morphea caused by COVID-19 infection, first polish case report

Cisoń,

Białynicki-Birula

2024

Our Dermatol Online

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Morphea, a localized scleroderma variant, is a rare dermatological condition characterized by fibrosis and thickening of the skin. While its etiology remains unclear, there have been reports of its association with viral infections, including COVID-19. We present a case of morphea in a 26-year-old female patient with a history of two episodes of COVID-19. The patient exhibited cutaneous lesions on her left forearm, bilateral axillae, and groin, accompanied by abdominal wall induration Laboratory investigations revealed no significant abnormalities, except for positive antinuclear antibodies (ANA) with various patterns. This case highlights the potential association between COVID-19 infection and the development of morphea, underscoring the importance of considering this relationship in patients presenting with dermatological manifestations following COVID-19. Further research is needed to elucidate the underlying mechanisms and optimize treatment strategies for such cases. Key words: COVID-19, Morphea, Post-COVID-19 Morphea, Skin diseases

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“…Typically, a single lesion on the upper back or extremities is observed ( 90 , 91 ). However, generalized forms may also occur exceptionally ( 92 ). In certain cases, injection or trauma prior to disease manifestation have been identified as potential triggers ( 92 – 94 ).…”

Section: Clinical Typesmentioning

confidence: 99%

Morphea: The 2023 update

et al. 2023

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Morphea, also known as localized scleroderma, is a chronic inflammatory connective tissue disorder with variable clinical presentations, that affects both adults and children. It is characterized by inflammation and fibrosis of the skin and underlying soft tissue, in certain cases even of the surrounding structures such as fascia, muscle, bone and central nervous system. While the etiology is still unknown, many factors may contribute to disease development, including genetic predisposition, vascular dysregulation, TH1/TH2 imbalance with chemokines and cytokines associated with interferon-γ and profibrotic pathways as well as certain environmental factors. Since the disease may progress to permanent cosmetic and functional sequelae, it is crucial to properly assess the disease activity and to initiate promptly the adequate treatment, thus preventing subsequent damage. The mainstay of treatment is based on corticosteroids and methotrexate. These, however, are limited by their toxicity, especially if applied long-term. Furthermore, corticosteroids and methotrexate often do not sufficiently control the disease and/or the frequent relapses of morphea. This review presents the current understanding of morphea by discussing its epidemiology, diagnosis, management and prognosis. In addition, it will describe recent pathogenetic findings, thus proposing potential novel targets for therapeutic development in morphea.

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A case of generalized morphea profunda following SARS-CoV-2 infection

Cited by 3 publications

References 9 publications

Linear Morphea in the Context of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Unique Dermatological Manifestation

Linear Morphea in the Context of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Unique Dermatological Manifestation

Morphea caused by COVID-19 infection, first polish case report

Morphea: The 2023 update

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