A Case of Giant Cell Tumour of Bone in a Dog

Blondel, Margaux; Gros, Lucile; Semin, Marie-Odile; Delverdier, Maxence; Palierne, Sophie; Autefage, A.

doi:10.1055/s-0039-3400513

Cited by 2 publications

(3 citation statements)

References 22 publications

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“…Canine GCTBs have been diagnosed as originating from the humerus, 26 accessory carpal bone, 27 scapula 28 and proximal tibia. 29 Metastases have been reported in regional lymph nodes, lungs, liver and other bones. 28 , 30 GCTBs have also been described in horses, laboratory rodents and avian species.…”

Section: Discussionmentioning

confidence: 99%

“… 20 , 22 , 25 , 27 In a case report with a dog with a stage III tibial GCTB, local recurrence occurred 5 months after surgery. 29 …”

Section: Discussionmentioning

confidence: 99%

“…20,22,25,27 In a case report with a dog with a stage III tibial GCTB, local recurrence occurred 5 months after surgery. 29 Following the human classification, this cat had a stage II GCTB and therefore our treatment approach should be considered appropriate.…”

Section: Discussionmentioning

confidence: 99%

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Vertebral giant cell tumour of bone in a domestic shorthair cat

Carrete¹,

Tabanez²,

Civello³

et al. 2023

Journal of Feline Medicine and Surgery Open Reports

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Case summary A 10-year-old male neutered domestic shorthair cat was presented with a 5-month history of progressive non-ambulatory paraparesis. Initial vertebral column radiographs revealed an L2–L3 expansile osteolytic lesion. Spinal MRI showed a well-demarcated, compressive expansile extradural mass lesion affecting the caudal lamina, caudal articular processes and right pedicle of the second lumbar vertebra. The mass was hypointense/isointense on T2-weighted images, isointense on T1-weighted images and had mild homogeneous contrast enhancement after gadolinium administration. MRI of the remaining neuroaxis and CT of the neck, thorax and abdomen with ioversol contrast revealed no additional neoplastic foci. The lesion was removed by en bloc resection via a dorsal L2–L3 laminectomy, including the articular process joints and pedicles. Vertebral stabilisation was performed with titanium screws placed within L1, L2, L3 and L4 pedicles with polymethylmethacrylate cement embedding. Histopathology revealed an osteoproductive neoplasm composed of spindle and multinucleated giant cells without detectable cellular atypia or mitotic activity. On immunohistochemical evaluation, osterix, ionised calcium-binding adaptor molecule 1 and vimentin labelling were observed. Based on the clinical and histological features, a giant cell tumour of bone was considered most likely. Follow-up at 3 and 24 weeks postoperatively demonstrated significant neurological improvement. Postoperative full-body CT at 6 months showed instability of the stabilisation construct but absence of local recurrence or metastasis. Relevance and novel information This is the first reported case of a giant cell tumour of bone in the vertebra of a cat. We present the imaging findings, surgical treatment, histopathology, immunohistochemistry and outcome of this rare neoplasm.

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Section: Discussionmentioning

confidence: 99%

“… 20 , 22 , 25 , 27 In a case report with a dog with a stage III tibial GCTB, local recurrence occurred 5 months after surgery. 29 …”

Section: Discussionmentioning

confidence: 99%

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Vertebral giant cell tumour of bone in a domestic shorthair cat

Carrete¹,

Tabanez²,

Civello³

et al. 2023

Journal of Feline Medicine and Surgery Open Reports

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Case report: Giant cell tumor of bone in the mandible of a goat—diagnostics, surgical treatment, and outcome

Biermann,

Piechl,

Dinhopl

et al. 2024

Front. Vet. Sci.

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Neoplastic processes of the mandible and their treatment are rarely reported in large animal species. Specifically, giant cell tumor of bone is an uncommon tumor in animals and has been associated in humans with locally invasive behavior and a high recurrence rate. En-bloc resection is the treatment of choice, but depending on the localization of the tumor, this may result in functional deficits. This report details the diagnostic work-up, treatment, and long-term outcome of a giant cell tumor of bone involving the rostral mandible and mandibular symphysis of a goat. Extensive rostral mandibulectomy involving the entire mandibular symphysis without surgical fixation of the hemimandibles was performed. Histological and electron microscopic findings of the tumor were consistent with a giant cell tumor of bone. Although a mutation of the H3F3A gene is considered the driver of tumor development in human giant cell tumors, using molecular analysis, this gene mutation could not be confirmed in this case. Follow-up examinations revealed spontaneous secondary fusion of both hemimandibles and no signs of tumor recurrence. Nearly 1 year after surgery, the owners reported no signs of tumor regrowth.

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A Case of Giant Cell Tumour of Bone in a Dog

Cited by 2 publications

References 22 publications

Vertebral giant cell tumour of bone in a domestic shorthair cat

Vertebral giant cell tumour of bone in a domestic shorthair cat

Case report: Giant cell tumor of bone in the mandible of a goat—diagnostics, surgical treatment, and outcome

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