A case of granuloma faciale successfully treated with systemic dapsone

Alsorori, Ezeldeen; Kiss, Norbert; Medvecz, Márta; Naqeshbandi, Ahmad Faiq; Bergler‐Czop, Beata; Alsarari, Inas; Cantisani, Carmen

doi:10.1111/dth.13162

Cited by 6 publications

(11 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the treatment of GF may be difficult. [4][5][6] Given the anti-inflammatory properties of minocycline, such as down-regulation of proinflammatory cytokine production and inhibition of neutrophil chemotaxis, we tried to evaluate the efficacy of minocycline in the treatment of GF.…”

Section: Introductionmentioning

confidence: 99%

A Case of Granuloma Faciale Successfully Treated with Minocycline

Liu,

He,

Chang

2023

CCID

View full text Add to dashboard Cite

Granuloma faciale (GF) is a rare chronic inflammatory dermatosis in clinical practice. The etiology is not yet clear, and it often occurs on the face. The progression of skin lesions is slow and persistent, with almost no self regression and a risk of recurrence, which may lead to disfigurement. We reported a 61-year-old male with GF who had poor reaction with topical corticosteroids and calcineurin inhibitors, but the lesions were significantly improved after systematic application of minocycline. This report describes the good clinical effect of minocycline on GF.

show abstract

Section: Introductionmentioning

confidence: 99%

A Case of Granuloma Faciale Successfully Treated with Minocycline

Liu,

He,

Chang

2023

CCID

View full text Add to dashboard Cite

show abstract

“…Granuloma faciale (GF) is an uncommon inflammatory dermatosis involving persistent reddish brown or violaceous patches, papules, nodules, or plaques. [ 1 2 3 ] Classically, it involves the face (especially, nose, forehead, and cheeks),[ 4 ] with extrafacial involvement being uncommon. [ 5 ] Lesions may demonstrate a smooth surface with superficial telangiectasia, follicular accentuation, and a peau d’orange appearance.…”

mentioning

confidence: 99%

“…[ 5 ] Lesions may demonstrate a smooth surface with superficial telangiectasia, follicular accentuation, and a peau d’orange appearance. [ 1 2 ] Ulceration is extremely rare. Although it is benign, it tends to be treatment resistant.…”

mentioning

confidence: 99%

See 1 more Smart Citation

A Case Series of Extrafacial Granuloma Faciale

Finnegan,

O’Connor,

Mhaolcatha

et al. 2024

Indian Journal of Dermatology

View full text Add to dashboard Cite

“…Rhinophyma-like GF, like the classic GF variant, 1,8 is very resistant to treatment. Clofazimine, 6 intralesional steroids injection, 3 surgery excision, 5 electrocautery, 4 and carbon dioxide laser 7 were performed with success.…”

mentioning

confidence: 99%

Rhinophyma‐like granuloma faciale

Allegue

Fachal

González‐Vilas

et al. 2021

Dermatologic Therapy

View full text Add to dashboard Cite

Granuloma faciale (GF) is a rare, chronic and asymptomatic inflammatory dermatosis characterized by papules, nodules, or plaques of facial location. Color varies from pink to reddish brown or purplish. It is considered a peculiar and chronic form of vasculitis, with a good prognosis and without systemic repercussions. 1,2 We present here a case of GF simulating a rhinophyma.A 60-year-old man, with past history of kidney transplant between 1997 and 2017 due to IgA glomerulonephritis and currently on dialysis due to atypical hemolytic uremic syndrome (aHUS), consulted for papular and nodular skin lesions that changed the contour of his nose. First symptoms appeared on 1999, and diagnosis of GF was made. The condition appeared despite being on immunosuppressive treatment due to his kidney transplant with cyclosporine A, mycophenolate mofetil, and prednisone. Powerful and intralesional topical corticosteroids were then tested without therapeutic response. Acceptable cosmetic results were obtained with cryosurgery, which persisted until 2 years ago, when he noted worsening of previous lesions. In 2015, cyclosporine A was replaced by tacrolimus due to chronic graft dysfunction and in 2017 eculizumab was started after the diagnosis of aHUS.Physical examination showed raised-pinkish papules appeared on a thickened and shiny skin with follicullar accentuation of the nose (Figure 1). Despite the fact that the patient already had a histopathological diagnosis of GF, two new skin biopsies (nodule and nasal tip) were performed. These showed diagnostic changes of GF (Figures 2 and 3).We performed again cryosurgery, three freeze-thaw cycles of 20 to 30 s at 1-month intervals. We achieved an acceptable cosmetic result without pigmentary changes or scarring (Figure 4). In the 6-month follow-up, there were no signs of recurrence.Granuloma faciale is a fairly predictive process in its presentation.

show abstract

A case of granuloma faciale successfully treated with systemic dapsone

Cited by 6 publications

References 11 publications

A Case of Granuloma Faciale Successfully Treated with Minocycline

A Case of Granuloma Faciale Successfully Treated with Minocycline

A Case Series of Extrafacial Granuloma Faciale

Rhinophyma‐like granuloma faciale

Contact Info

Product

Resources

About