A case of Graves' disease with anti-triiodothyronine antibodies.

Sakata, Shigeki; Komaki, Takashi; Nakamura, Shigenori; Kamikubo, Keita; Takakuwa, Kaoru; Kametani, Masaaki; Tokimitsu, Naoki; Miura, Kiyoshi

doi:10.1507/endocrj1954.32.181

Endocrinol Japon

1985

DOI: 10.1507/endocrj1954.32.181

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A case of Graves' disease with anti-triiodothyronine antibodies.

Shigeki Sakata

Takashi Komaki

Shigenori Nakamura

et al.

Abstract: A case of Graves' disease with high serum thyroxine (T4) and low triiodothyronine (T3) levels which was therefore initially diagnosed as a T4-thyrotoxicosis is reported.

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1985

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Cited by 12 publications

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References 21 publications

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“…With regard to changes in THAA activity during treatments such as thyroid hormone replacement, antithyroid drugs, subtotal thyroidectomy, and glucocorticoids, only a few reports have been published (Ochi et al, 1972;Faerch et al, 1980 ;Nakamura et al, 1982;Sakata et al, 1985b). Furthermore, the relationship between titers of THAA and anti-thyroglobulin (Tg) antibodies has not yet been clarified (Staeheli et al, 1975 ;Nakamura et al, 1983), although THAA are thought to be antibodies to antigenic site(s) of Tg which contains thyroid hormones (Pearce et al, 1981 ;Byfield et al, 1982).…”

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Thyroid hormone autoantibodies (THAA) in two cases of Graves' disease: Effects of antithyroid drugs, prednisolone, and subtotal thyroidectomy.

et al. 1986

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Changes in titers of serum thyroid hormone autoantibodies (THAA) and anti-thyroglobulin (Tg) antibodies during treatment with antithyroid drugs (methimazole and propylthiouracil) were examined in two cases of Graves' disease. Effects of prednisolone and subtotal thyroidectomy were also investigated in one case (case 1). Initially both cases had only anti-T4 autoantibodies in their serum. During methimazole therapy, the titer of and-T4 autoantibodies increased in both cases, and anti-T3 autoantibodies became detectable and their titer increased in case 2. The influence of propylthiouracil on the titer of THAA was not clear. Both prednisolone plus methimazole therapy and subtotal thyroidectomy decreased the level of and-T4 autoantibodies in case 1. There was a significant correlation between titers of THAA and antiTg antibodies in both cases, although titers of and-Tg antibodies in case 1 stayed within the normal range throughout the investigation period. These results indicate that 1) methimazole treatment could induce and/or enhance the production of THAA and 2) THAA are antibodies against thyroid hormonecontaining Tg molecule.

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confidence: 99%

Thyroid hormone autoantibodies (THAA) in two cases of Graves' disease: Effects of antithyroid drugs, prednisolone, and subtotal thyroidectomy.

et al. 1986

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Circulating thyroid hormone autoantibodies

Benvenga

Trimarchi

Robbins

1987

J Endocrinol Invest

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A case of diabetes mellitus associated with anti-insulin autoantibodies without previous insulin injection

Sakata

Nagai

Imai

et al. 1987

J Endocrinol Invest

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A case of diabetes mellitus who had high levels of fasting immunoreactive insulin (IRI) and low levels of immunoreactive C-peptide (CPR) is reported. Examination of her serum disclosed the presence of IgG class k + lambda type anti-insulin autoantibodies. She has never been treated with insulin, nor had drugs which have been reported to be responsible for inducing insulin autoimmune syndrome. Despite the presence of autoantibodies against insulin, she has never experienced hypoglycemia. Significance of the production of autoantibodies against insulin and physicochemical parameters of anti-insulin antibodies in her serum are discussed.

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A case of Graves' disease with anti-triiodothyronine antibodies.

Abstract: A case of Graves' disease with high serum thyroxine (T4) and low triiodothyronine (T3) levels which was therefore initially diagnosed as a T4-thyrotoxicosis is reported.

Cited by 12 publications

References 21 publications

Thyroid hormone autoantibodies (THAA) in two cases of Graves' disease: Effects of antithyroid drugs, prednisolone, and subtotal thyroidectomy.

Thyroid hormone autoantibodies (THAA) in two cases of Graves' disease: Effects of antithyroid drugs, prednisolone, and subtotal thyroidectomy.

Circulating thyroid hormone autoantibodies

A case of diabetes mellitus associated with anti-insulin autoantibodies without previous insulin injection

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