A case of gross hematuria and IgA nephropathy flare-up following SARS-CoV-2 vaccination

IgA nephropathy presenting as rapidly progressive glomerulonephritis following first dose of COVID-19 vaccine

“…Unlike previous observations [ 2 , 3 ], this report suggests that development of IgAN following COVID-19 vaccination may occur after the first dose of vaccine, and may present as a rapidly progressive glomerulonephritis leading to severe AKI. As with other case reports, COVID-19 vaccine responsibility in the IgAN flare-up reported here remains difficult to establish.…”

“…Coronavirus disease 2019 (COVID-19) has recently been associated with kidney disease in pediatric patients [ 1 ]. Interestingly, COVID-19 vaccination has also been described as a potential trigger of acute kidney injury (AKI); in particular, IgA nephropathy (IgAN) flare-ups following mRNA COVID-19 vaccination have been reported in adult [ 2 ] and pediatric patients [ 3 ]. However, the pediatric cases published so far described patients suffering from mild IgAN flare-ups occurring after the second dose of the COVID-19 vaccine.…”

As Signals From the Kawasaki-Like Illness During the COVID-19 Pandemic: Is It Possible That the Incidence of IgA Nephropathy May Increase in the Future

“…Based on the data reported, it is currently impossible to conclude that there is a causal link. To our knowledge, nine cases of hematuria due to IgA deposit nephropathy have been reported so far (22)(23)(24)(25).…”

Canagliflozin Markedly Decreased Proteinuria in a Patient With IgA Nephropathy

“…Abramson et al report newly diagnosed IgAN in a kidney biopsy after a man presented with gross hematuria and proteinuria 24 hours after a COVID-19 vaccine [7]. In addition, there are two recent reports [8,9] of three patients with prior biopsy-proven IgAN presenting with gross hematuria usually with increased proteinuria within 24 hours of the second dose of SARS-CoV-2 vaccine. Once the vaccine is injected, mRNA encoding prefusionstabilized spike glycoprotein is translated by host cells, and major histocompatibility complex molecules subsequently present viral protein segments to elicit immune responses with antibody production, including IgG/A/M.…”