A Case of Henoch-Schoenlein Purpura in Hemophilia

Abstract

A 25-year-old male, white, with severe hemophilia B (F.IX < 1%) developed a rash of small erythematous macules, purpuric spots and petechia on the lower extremities. These skin lesions were discrete, not pruritic, not papular and with no areas of necrosis. No relationship to previous infection was determined. As the patient did not present any other clinical alteration, he was observed daily on an ambulatory basis in a four days’ period, without any medication. On the fifth day parallel to the disappearance of the skin lesions, the patient began to complain of abdominal pain, in crisis of moderate intensity. As the abdominal discomfort increased rapidly on the following 24 hours, we introduced specific therapy on an in-patient basis. The case evolved to an acute abdominal picture that required surgical intervention. The laparathomy resulted in large ressections of jejunum and ileum that showed large hemmorrhagic and necrotic areas. The post-operative period elapsed without incidents and the patient left the hospital in three weeks. This case that at the beginning could not give us a clear diagnosis of an anaphylactoid purpura shows us once more that in hemophilia, we must transfuse as early as possible.

Hepatitis A Virus Transmission in Brazilian Hemophiliacs

“…Moreover, the high recovery experienced with SD treatment and its ease of implementation increased the availability of affordable coagulation factor concentrate in our region. Our interest in SD was further increased by the transmission of HIV, HBV and HCV to hemophilia B patients in our region by a factor IX concentrate that we prepared using dry heat at 60 O C for 72 h; AHF prepared from the same plasma pool but processed with SD was shown not to transmit these viruses [6]. We now wish to report on our experience, summarized in table 1.…”

“…Of them, 7 (63.6%) were found positive for IgG/HAV. Group D: 28 children, average age = 6.8 years (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) whose parents work at our institution were tested, 6 (2 1.4%) were HAV IgG positive. Group E: Of 148 blood donors, average age = 28.6 years (18-54), 92 (62.6%) were found positive for HAV IgG.…”