A case of Henoch-Schönlein purpura associated with scrub typhus

Im, Jae Hyoung; Choi, Suk Jin; Chung, Moon-Hyun; Lee, Seung Yun; Park, Young Kyoung; Kwon, Hea Yoon; Baek, Ji Hyeon; Lee, Jin Soo

doi:10.1186/s12879-020-05001-x

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…This is an accurate and precise tool to corroborate the etiology. 16 The current guidelines for the treatment of scrub typhus include doxycycline 100 mg twice daily.…”

Section: Discussionmentioning

confidence: 99%

Leukocytoclastic Vasculitis

Vasireddy¹,

Pai²,

Shetty³

et al. 2023

Sultan Qaboos Univ Med J

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Scrub typhus is a disease endemic to the Indian subcontinent caused by the obligate intracellular pleomorphic organism, Orientia tsutsugamushi. Scrub typhus among other acute febrile illnesses present with prodromal symptoms of fever, malaise, myalgia, anorexia followed by a distinct maculopapular rash, hepatosplenomegaly, and lymphadenopathy. In this case report, we present a patient who developed a rare cutaneous vasculitis secondary to infection with Orientia tsutsugamushi. After performing the Weil Felix test, a diagnostic titer of 1:640 against OX-K was obtained. Furthermore, a skin biopsy was carried out which confirmed the diagnosis of leukocytoclastic vasculitis. The patient was treated with Doxycycline and showed a drastic improvement in his symptoms. Keywords: Scrub Typhus, Rickettsia; Vasculitis; Doxycycline.

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“…This is an accurate and precise tool to corroborate the etiology. 16 The current guidelines for the treatment of scrub typhus include doxycycline 100 mg twice daily.…”

Section: Discussionmentioning

confidence: 99%

Leukocytoclastic Vasculitis

Vasireddy¹,

Pai²,

Shetty³

et al. 2023

Sultan Qaboos Univ Med J

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“…Scrub typhus (ST), also known as bush typhus or tsutsugamushi disease, is a zoonotic vector-borne disease caused by Orientia tsutsugamushi (OT), which is usually transmitted by the bite of a chigger mite and leads to illness from non-speci c symptoms, such as fever, headache, swollen lymph nodes, abdominal pain, a rash or scab at the site of the bite, to severe diseases such as bronchitis, pneumonia, myocarditis, and meningitis [3,4]. The diagnosis of scrub typhus is mainly based on laboratory tests including serological analysis and some molecular assays targeting speci c genes speci c of OT.…”

Section: Introductionmentioning

confidence: 99%

A case of pulmonary tuberculosis patient complicated with hemorrhagic fever with renal syndrome and scrub typhus in Yunnan, China: a case report

Hao

Kong

Yin

et al. 2023

Preprint

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Background Hemorrhagic fever with renal syndrome (HFRS) caused by Orthohantavirus (OHV) and scrub typhus (ST) caused by Orientia tsutsugamushi (OT) are two infectious diseases prevalent in southwest China. Rodents are the natural host and the main source of the two diseases. OT infection to humans is usually resulted from bite of an infective chigger mite on rodents, and OHV is transmitted through contact or inhalation of aerosols and secretions from infected rodent. For infectious diseases, the use of antibiotics and hormones is essential, so the diagnosis of complex situations is not easy under the action of drugs. Clinically, fever is the first symptom of these two diseases, and most of them are accompanied by common symptoms such as chills and headaches. The clinical symptoms of these two diseases are very similar, so it is easy to diagnose and miss diagnosis. Case presentation: In this case, a 44-year-old male famer with a history of working in coal transportation was admitted to the hospital because of respiratory symptoms accompanied by fever, headache, and skin rashes on his body. Biochemical and urinalysis revealed the hepatic and renal injury. The subsequent molecular testing confirmed he suffered from HFRS and scrub typhus simultaneously that the serological and clinical diagnosis could not identify the cause of infection before. Such case has not been reported in Yunnan Province before. Conclusion As the clinical findings of HFRS and scrub typhus are similar and usually unspecific, the clinical diagnosis should be made with a combination of serological and etiological approaches. In the endemic areas of the two diseases, potential HFRS and ST patients should be precisely distinguished with more tests, which is critical for developing proper treatment plans.

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“…Scrub typhus (ST), also known as bush typhus or tsutsugamushi disease, is a zoonotic vector-borne disease caused by Orientia tsutsugamushi (OT), which is usually transmitted by the bite of a chigger mite and leads to illness from non-specific symptoms, such as fever, headache, swollen lymph nodes, abdominal pain, a rash or scab at the site of the bite, to severe diseases such as bronchitis, pneumonia, myocarditis, and meningitis [ 5 , 6 ]. The diagnosis of scrub typhus is mainly based on laboratory tests including serological analysis and some molecular assays targeting the 56-kDa type specific antigen (TSA) gene of OT.…”

Section: Introductionmentioning

confidence: 99%

A case of pulmonary tuberculosis patient complicated with hemorrhagic fever with renal syndrome and scrub typhus in Yunnan, China: a case report

Huang,

Kong,

Yin

et al. 2023

BMC Infect Dis

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Background Hemorrhagic fever with renal syndrome (HFRS) caused by Orthohantavirus (OHV) and scrub typhus (ST) caused by Orientia tsutsugamushi (OT) are two infectious diseases prevalent in southwest China. Rodents are the natural host and the main source of the two diseases. OT infection to humans is usually resulted from bite of an infective chigger mite on rodents, and OHV is transmitted through contact or inhalation of aerosols and secretions from infected rodent. The use of antibiotics and hormones is crucial for infectious diseases, although the clinical manifestations are not obvious and a definitive diagnosis becomes more difficult in the presence of these drugs. Clinically, fever is the first symptom of these two diseases, and most of them are accompanied by common symptoms such as chills and headaches. The clinical symptoms of these two diseases are very similar and therefore it is not easy to make a differential diagnosis. Case presentation In this case, a 44-year-old male famer with pulmonary tuberculosis and a history of working in coal transportation was admitted to the hospital because of respiratory symptoms accompanied by fever, headache, and skin rashes on his body. Biochemical and urinalysis revealed the hepatic and renal injury. The subsequent molecular testing confirmed he suffered from HFRS and scrub typhus simultaneously that the serological and clinical diagnosis could not identify the cause of infection before. Such case has not been reported in Yunnan Province before. Conclusion The clinical diagnosis should be combined with serological and nucleic acid testing approaches for differential diagnosis in areas where HFRS and ST are endemic.

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A case of Henoch-Schönlein purpura associated with scrub typhus

Cited by 4 publications

References 16 publications

Leukocytoclastic Vasculitis

Leukocytoclastic Vasculitis

A case of pulmonary tuberculosis patient complicated with hemorrhagic fever with renal syndrome and scrub typhus in Yunnan, China: a case report

A case of pulmonary tuberculosis patient complicated with hemorrhagic fever with renal syndrome and scrub typhus in Yunnan, China: a case report

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