A case of human angiostrongyliasis manifesting as eosinophilic meningitis in Okinawa, Japan

Todaka, Takafumi; Oshiro, Yusuke; Shinzato, Takashi

doi:10.1016/j.parint.2020.102124

Cited by 3 publications

(8 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inhabitants can be exposed to A cantonensis by eating intermediate or paratenic hosts, or vegetables contaminated by larvae. [ 10 ]…”

Section: Discussionmentioning

confidence: 99%

“…Most human angiostrongyliasis manifests itself as eosinophilic meningitis or meningoencephalitis, the clinical features are quite obvious with respect to peripheral blood and CSF eosinophilia, neurolgical disorders including headache, myalgia, and some nonspecific symptoms such as nausea and fainting. [ 2 , 4 , 9 , 10 ] However, a timely diagnosis is not easy to achieve in clinical practice. Delayed diagnosis is quite common, as many patients were not correctly diagnosed until 2 or 3 weeks after hospitalization.…”

Section: Discussionmentioning

confidence: 99%

“…Peripheral eosinophilia provided a vital clue. Eosinophilia can be considered part of drug allergy, as many patients with A cantonensis would have received various drugs when the therapeutic efficacy was unsatisfactory, [ 10 ] but eosinophilia is almost unexceptionally present in all patients infected with A cantonensis at the beginning of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…A review of several recent case reports of human A cantonensis showed that few of these cases reported a positive finding of A cantonensis directly. [4,10–13]…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

High-throughput metagenomics analysis in early and precise diagnosis of eosinophilic meningoencephalitis complicated with respiratory failure: A case report

et al. 2023

View full text Add to dashboard Cite

Rationale: Human infection with Angiostrongylus cantonensis is uncommon and has only been sporadically reported in the literature. Patients infected with A cantonensis usually have a delayed diagnosis and sometimes a poor prognosis. Patient concerns: A 70-year-old woman presented to the respiratory department with complaints of headache, chest pain, myalgia, fatigue, and anorexia for 7 days. Diagnoses: Complete blood count showed eosinophilia. The serum was tested showing a positive finding of A cantonensis antibody. Cerebrospinal fluid was tested using high-throughput metagenomics analysis and 16 reads for A cantonensis were mapped. The patient was diagnosed with A cantonensis infection. Interventions: The patient received a 7-day course of albendazole and 4-day course of prednisone. Outcomes: When discharged from the hospital, the patient still suffered from fatigue and poor memory. Aminotransferase levels were high due to albendazole’s liver toxicity. In a post-discharge follow-up about 1 month later she had recovered completely both physically and mentally, and peripheral eosinophil count and aminotransferase levels were both normal. Lessons: Because the direct identification of parasites is difficult, high-throughput metagenomics analysis may provide a reliable alternative tool for the diagnoses of infection with A cantonensis . When albendazole is prescribed, caution must be taken with respect to its liver toxicity.

show abstract

“…Inhabitants can be exposed to A cantonensis by eating intermediate or paratenic hosts, or vegetables contaminated by larvae. [ 10 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…A review of several recent case reports of human A cantonensis showed that few of these cases reported a positive finding of A cantonensis directly. [4,10–13]…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

High-throughput metagenomics analysis in early and precise diagnosis of eosinophilic meningoencephalitis complicated with respiratory failure: A case report

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Its worldwide distribution has shown increasing diversity, compared to the fact that it is endemic in Southeast Asia and the Pacific Basin. Although many cases occurred in Hawaii, Vietnam and Thailand, there were also reports from Asian countries that are not endemic to this parasite, such as Japan, China and India, and cases from Oceania, specially a case reported in Australia (Wang et al, 2018;Berkhout et al, 2019;Tiwari et al, 2019;Todaka et al, 2020).…”

Section: Methodsmentioning

confidence: 99%

Epidemiological, clinical and laboratory aspects of Angiostrongylus cantonensis infection: an integrative review

Carvalho

Santos

et al. 2022

Braz. J. Biol.

View full text Add to dashboard Cite

This integrative literature review study analyzes the findings of the last 5 years of the parasite Angiostrongylus cantonensis. It is known that this nematode is found in the pulmonary arteries of rats, where it remains as a definitive host. From mice, the cycle spreads to animals, such as snails, which in contact with humans can trigger the disease. In humans, the parasite causes several neurological, abdominal manifestations and mainly meningitis. Based on the review of studies, its epidemiology shows worldwide distribution, although there are endemic cases for this parasite, such as asian countries. Laboratory findings generally showed altered CSF with turbidity, increased protein and eosinophilia, which generated meningeal signs in the patient, moreover MRI exams showed multiple alterations. Rare findings of the nematode in the eyeball, lung and signs of peritoneal inflammation were reported, which requires further studies to understand the whole pathophysiology. Finally, conservative treatment based on anthelmintics and anti-inflammatories brought good responses, although there are reports of deaths, which demonstrates the importance in the prevention and therapy of this disease.

show abstract

Re-Emerging, Under-Recognized Zoonotic, and Neglected Tropical Diseases in Hawaiʻi

Zorilla,

Ching,

Elisara

et al. 2024

Jpn J Infect Dis

View full text Add to dashboard Cite

Hawaiʻi, the United States' most western geographic state in the Pacific, is intermediate between the North and South American continents and Indo-Pacific regions, including Japan. The Hawaiian Islands' tropical environmental conditions provide favorable ecosystems for various infectious pathogens, their vectors, and reservoirs. This creates a conducive environment for transmission of various zoonotic diseases that affect both humans and animals. Hawaiʻi has experienced an increase in outbreaks of dengue, leptospirosis, and murine typhus. Further, toxoplasmosis and neuroangiostrongyliasis cases remain prevalent throughout the state, and the putative presence of autochthonous Zika cases in a retrospective study may be of national public health concern.Understanding the factors that affect the transmission and distribution of zoonoses is necessary to identify at-risk places and populations. The One Health approach seeks to understand, report, and interpret these factors and requires collaborations between private and government institutions.One Health should focus its efforts on neglected tropical diseases (NTD) and prioritize intervention development to control and prevent the transmission of diseases that spread between animals and humans. This review will focus on the epidemiological and clinical characteristics of underrecognized zoonotic and NTD affecting Hawaiʻi: leptospirosis, murine typhus, neuroangiostrongyliasis, toxoplasmosis, dengue, and Zika infections.

show abstract

A case of human angiostrongyliasis manifesting as eosinophilic meningitis in Okinawa, Japan

Cited by 3 publications

References 8 publications

High-throughput metagenomics analysis in early and precise diagnosis of eosinophilic meningoencephalitis complicated with respiratory failure: A case report

High-throughput metagenomics analysis in early and precise diagnosis of eosinophilic meningoencephalitis complicated with respiratory failure: A case report

Epidemiological, clinical and laboratory aspects of Angiostrongylus cantonensis infection: an integrative review

Re-Emerging, Under-Recognized Zoonotic, and Neglected Tropical Diseases in Hawaiʻi

Contact Info

Product

Resources

About