A case of human rabies with a long incubation period in Wuhan

Abstract

Highlights We report one case of human rabies with a long incubation period in Wuhan, China. In Wuhan, many free-roaming dogs are not only dangerous to domestic dogs and livestock, they are also a threat to humans. Epidemiology of rabies with emphasis on its potential to spread in urban-rural fringe in Wuhan has been discussed. The elimination of RABV from free-roaming domestic dogs will drive a considerable reduction in human disease. We showed that the efficient collaboration was important between the hospital and a professional laboratory for rabies diagnosis.

A Case of Atypical Rabies with Adams-Stokes Syndrome ： a case report

“…The DNA sequence alignments indicated high concordance between the suspected viral sequence and the Rabies lyssavirus genome (JQ970483.1). Detection of saliva samples by reverse transcription polymerase chain reaction (RT-PCR) and detection of antibodies to rabies virus by serum and spinal uid are the tests used for rabies diagnosis [12]. We intended to con rm our hypothesis by testing saliva samples from the patient using RT-PCR assays or by collecting serum and spinal uid for antibody testing.…”

Of love and other demons: depicting human rabies in Colombia

“…Human rabies disease is characterized by five clinical stages from the incubation period to death. According to Udow et al., the overall mean incubation period is 54 days, but with an average of 64 days for dog bites and 51 days for bat bites; although in rare cases, incubation periods can be greater than several years [ 10 , 11 , 12 ]. Average survival is usually between one and two weeks from clinical onset, yet rare cases have lasted more than one month [ 3 , 13 ]; furthermore, location of the bite is related to prognosis, as also stated in the book: “The wound was far from the area of greatest risk, and no one recalled any bleeding.…”

Can Rabies Infection have an Abortive Phase? Need for Further Evidence to Understand Rabies Epidemiology

“…These incidents need further validation from experts all over the world to put rabies epidemiology in perspective and to know if rabies infection has an abortive phase due to the strong innate response of the infected individuals, mammals or bovines. 15 Scientists are baffled by the long incubation periods 16 in rabies and natural antibodies in living organisms without vaccination. Hemachudha et al 17 in their chapter describe that during most of the incubation, RABV lies in the muscle as a so called smouldering, or low-replication-rate, infection.…”