A Case of Hypertensive Keratouveitis with Endotheliitis Associated with Cytomegalovirus

Yamauchi, Yasuyuki; Suzuki, Jun; Sakai, Jun‐ichi; Sakamoto, S.; Iwasaki, Takuya; Usui, Masahiko

doi:10.1080/09273940701486795

Cited by 32 publications

(17 citation statements)

References 6 publications

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“…During the same period, 51 eyes of 48 patients with CMV endotheliitis (Figure 3) were analyzed, and all were from Asian populations [6,8,[16][17][18][19][20][21][22][23][24]. Unlike eyes with anterior uveitis, the KPs in eyes with corneal endotheliitis tended to be pigmented, and were often arranged in a linear or coin-shaped pattern (Table 2).…”

Section: Corneal Endotheliitismentioning

confidence: 99%

“…It is interesting that 20 eyes had been treated previously for hypertensive anterior uveitis and were receiving corticosteroids at the time of diagnosis of the endotheliitis [6,[16][17][18]23]. Furthermore, two eyes with anterior uveitis had been noted to have concomitant endotheliitis lesions [7].…”

Section: Endotheliitis In Eyes With Previous Anterior Uveitismentioning

confidence: 99%

“…Anshu et al [19] and Miyanaga et al [8] found severe endo thelial cell loss in their patients, ranging from 35 to 77% (15 eyes [9%]), and, particularly for the 48 treatment episodes of eyes with endotheliitis, 12 (25%) had significant persistent corneal edema despite resolution of inflammation [6,[16][17][18][19]22,23]. In addition, persistent edema was also seen in two eyes with anterior uveitis [6], of which one was severe enough to require a corneal graft.…”

Section: Endothelial Cell Loss And/or Corneal Decompensationmentioning

confidence: 99%

“…1 Valganciclovir 1800 mg/day for 4 months Responded, but had persistent corneal edema 16 months posttreatment [23] Other treatment regimens Shiraishi et al…”

Section: Systemic Therapymentioning

confidence: 99%

See 3 more Smart Citations

Cytomegalovirus-associated anterior segment infection

Jap

Chee

2011

Expert Review of Ophthalmology

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Section: Corneal Endotheliitismentioning

confidence: 99%

Section: Endotheliitis In Eyes With Previous Anterior Uveitismentioning

confidence: 99%

Section: Endothelial Cell Loss And/or Corneal Decompensationmentioning

confidence: 99%

“…1 Valganciclovir 1800 mg/day for 4 months Responded, but had persistent corneal edema 16 months posttreatment [23] Other treatment regimens Shiraishi et al…”

Section: Systemic Therapymentioning

confidence: 99%

See 2 more Smart Citations

Cytomegalovirus-associated anterior segment infection

Jap

Chee

2011

Expert Review of Ophthalmology

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“…[1][2][3][4][5][6][7][8] In this case, we detected CMV antigen in the corneal stroma of a patient with corneal endotheliitis. Pathological findings revealed the typical 'owl's eye' appearance in the deep corneal stroma, similar to a previous report using confocal microscopy.…”

Section: Commentmentioning

confidence: 99%

Corneal endotheliitis with cytomegalovirus infection of corneal stroma

Shimazaki

Harashima

Tanaka

2009

Eye

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Herpesvirus detection and cytokine levels (IL‐10, IL‐6, and IFN‐γ) in ocular fluid from Tunisian immunocompetent patients with uveitis

Nahdi

Abdelwahed

Boukoum

et al. 2013

Journal of Medical Virology

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Human herpesviruses (HHVs) are involved in the pathogenesis of different types of uveitis. Cytokine response plays an important role in virus-induced immunopathology. This study aimed to investigate the incidence of HHVs in aqueous humor samples of immunocompetent patients with suspected viral uveitis and cytokine (IL-10, IL-6, and IFN-γ) expression profiling. Forty-seven aqueous humor samples were collected from immunocompetent patients with viral uveitis. Samples were assayed for HHV-1 to HHV-8 by in-house real-time polymerase chain reactions. IL-6, IL-10, and IFN-γ were quantified with a cytometric bead array. Relations between viral detection, cytokine profiles, and clinical data were studied. At least one viral genome was detected in 21 aqueous humor samples analyzed. Varicella-zoster virus (VZV) was detected in 14 of the positive samples, cytomegalovirus (CMV) in 8, HSV-1 in 1, Epstein-Barr virus (EBV) in 4, and HHV-6 in 2. More than one viral genome was detected in seven aqueous humor samples. Aqueous humor samples positive for HHV-DNA contained significant levels of IL-6, IL-10, and IFN-γ, compared to HHV-DNA negative samples. High levels of IL-6 were detected in patients with CMV-DNA in their aqueous humor samples. Significantly higher levels of IL-10 and IFN-γ were found in positive samples for VZV, EBV, and HHV-6 DNA than in negative aqueous humor ones. VZV was the principal etiologic agent of uveitis in this Tunisian series, with CMV the second most common agent. Knowledge of immunoregulatory interactions and dynamic changes in viral uveitis may be a key to understand the pathogenesis leading to more-effective treatments.

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A Case of Hypertensive Keratouveitis with Endotheliitis Associated with Cytomegalovirus

Abstract: The authors reported a case of hypertensive keratouveitis with endotheliitis associated with cytomegalovirus.

Cited by 32 publications

References 6 publications

Cytomegalovirus-associated anterior segment infection

Cytomegalovirus-associated anterior segment infection

Corneal endotheliitis with cytomegalovirus infection of corneal stroma

Herpesvirus detection and cytokine levels (IL‐10, IL‐6, and IFN‐γ) in ocular fluid from Tunisian immunocompetent patients with uveitis

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