A case of idiopathic eosinophilic pneumonia in a Quarter Horse gelding

Trimble, A. C.; Beard, Laurie A.; Davis, Elizabeth G.

doi:10.1111/eve.12753

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…Rare but debilitating, these conditions are a research priority in human medicine (Bochner et al ; Khoury et al ; O'Sullivan and Bochner ). Horses suffer from EADs, including those that affect isolated body systems (Dixon et al ; Lankveld ; Uhlhorn et al ; Climent et al ; Loibl et al ; Archer et al ; Lassaline‐Utter et al ; Luethy et al ; Trimble et al ), as well as multisystemic eosinophilic epitheliotropic disease (MEED), which affects multiple body systems simultaneously (Bosseler et al ). Lesions can occur in the gastrointestinal tract, skin, liver, pancreas, lymph nodes, kidney, bile ducts and respiratory tract (Bosseler et al ; Pucheu‐Haston and Del Piero ).…”

Section: Allergic Skin Diseasementioning

confidence: 99%

Eosinophils of the horse: Part II: Eosinophils in clinical diseases

Brosnahan

2020

Equine Veterinary Education

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Interpretation of eosinophilia in body fluids or tissues is often not straightforward. Eosinophil counts vary among clinically healthy individuals, and considerable overlap can occur between normal and affected animals in conditions such as allergic airway disease. Parasite exposure is a confounding factor when counts are increased, and in cases where very high counts and dramatic clinical signs make another disease process obvious, the underlying pathology may be uncertain and treatment difficult. Eosinophils are a component of the immune response in many diseases of the horse, but their specific role is often unknown and likely multifactorial. In helminth infections, eosinophils are assumed to be part of the normal host response to a pathogen, whereas in multisystemic eosinophilic epitheliotropic disease (MEED), the predominance of eosinophils likely represents a wildly dysregulated response, or an abnormal response altogether. This distinction is still not clear for other diseases. Understanding the pathways involved in recruitment, activation or suppression of eosinophils is required for more accurate diagnostics, effective therapeutics, and successful strategies for prevention of eosinophil associated diseases. Eosinophils of the horse: Part II reviews published observations on the eosinophil in clinical diseases of the horse. The behaviour of eosinophils in three common and relatively wellstudied conditions is presented first, including gastrointestinal helminth infections, non-infectious respiratory disease, and insect bite hypersensitivity. The less common eosinophilassociated diseases such as eosinophilic disease confined to the intestine (EDCI) and MEED are considered, followed by a brief summary of the eosinophil in phycomycosis and neoplasia. In conclusion, a panoramic view of the equine eosinophil as presented in Parts I and II is placed in the larger context of current eosinophil research, and areas of study are identified that may improve our understanding of eosinophil biology in equine health and clinical disease. Gastrointestinal parasites of the horse Gastrointestinal helminths are a widespread and well-studied problem in the horse. Clinical disease is associated historically with migratory large strongyles (Strongylus vulgaris, S. edentatus, S. equinus), small strongyles (cyathostomes), tapeworms (Anoplocephala perfoliata) and, in foals, ascarids (Parascarus equorum). Early studies sought to define parasite life cycles, but post-infection necropsies also described the eosinophilic response (Duncan and Pirie 1975). Host immunity and anthelmintics were the focus of later works (Bailey et al. 1989; Steuer et al. 2018). Variables exist across studies, including dosing variations, natural versus experimental

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